PLEKHB1 and RAP1GDS1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PLEKHB1	RAP1GDS1
Gene Name		pleckstrin homology domain containing, family B (evectins) member 1	RAP1, GTP-GDP dissociation stimulator 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Binding Protein C-terminus Binding Protein Homodimerization Activity	GTPase Activator Activity
	Biological Process	Multicellular Organismal Development Phototransduction Regulation Of Cell Differentiation	Vascular Smooth Muscle Contraction Myosin Filament Assembly Positive Regulation Of Rho GTPase Activity Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways
Drugs
Diseases
GWAS			Biochemical measures ( 19260141)
Protein-Protein Interactions		8 interactors: ACVR1 ATXN1 BMPR1B GNGT1 RAP1GDS1 SMAD1 TGFBR1 ZDHHC17	13 interactors: CDC42 DOC2A EGFR HRAS KIFAP3 KRAS MBIP NRAS PLEKHB1 RAC1 RAP1A RHOA ZNF451
Entrez ID		58473	5910
HPRD ID		09630	11763
Ensembl ID		ENSG00000021300	ENSG00000138698
Uniprot IDs		Q9UF11	B3KNU0 P52306 Q6U7G8
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Cartilage Development Positive Regulation Of Ossification Regulation Of Signaling Regulation Of Osteoblast Differentiation Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Pharyngeal System Development Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Ossification Regulation Of Extrinsic Apoptotic Signaling Pathway Gamete Generation Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Sexual Reproduction Positive Regulation Of Bone Mineralization Multicellular Organismal Reproductive Process Organ Development Positive Regulation Of Biomineral Tissue Development Multicellular Organism Reproduction Cell Fate Commitment Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Organ Morphogenesis Urogenital System Development Reproduction Eye Development Regulation Of Bone Mineralization Signaling Inflammatory Response Cell Communication Mesoderm Formation Endocardial Cushion Cell Fate Commitment Mesoderm Morphogenesis Single Organism Reproductive Process Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Heart Development Reproductive Process Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Neurotrophin TRK Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Activation Of MAPKK Activity Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Response To Wounding Positive Regulation Of Rac Protein Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Fc Receptor Signaling Pathway Axonogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Chemotaxis Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Neuron Projection Morphogenesis Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Epithelium Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Positive Regulation Of DNA Replication Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Ras Protein Signal Transduction Neuron Projection Development Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Cell Migration Cell Projection Morphogenesis
Tagcloud ?			adapted af4 aml1 b2a2 b3a2 considerations consuming correspondence e1a2 e2a enl evaluable expensive laborious leukemic lymphoblastic mll multicenter multiplex nup98 p190 p210 pallisgaard pbx1 rt sil strengthen tal1 tel
Tagcloud (Difference) ?			adapted af4 aml1 b2a2 b3a2 considerations consuming correspondence e1a2 e2a enl evaluable expensive laborious leukemic lymphoblastic mll multicenter multiplex nup98 p190 p210 pallisgaard pbx1 rt sil strengthen tal1 tel
Tagcloud (Intersection) ?