NCOA2 and EP300

Number of citations of the paper that reports this interaction (PMID 10490106)
166

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, two hybrid)
HPRD (in vitro, in vivo)

		NCOA2	EP300
Gene Name		nuclear receptor coactivator 2	E1A binding protein p300
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Histone Acetyltransferase Complex Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Thyroid Hormone Receptor Coactivator Activity Nuclear Hormone Receptor Binding Protein Dimerization Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Activating Transcription Factor Binding P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Transferase Activity, Transferring Acyl Groups Chromatin DNA Binding Activating Transcription Factor Binding Nuclear Hormone Receptor Binding Androgen Receptor Binding Pre-mRNA Intronic Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Glucose Metabolic Process Histone Acetylation Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Circadian Regulation Of Gene Expression Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor Activity	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Response To Hypoxia Somitogenesis Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Internal Protein Amino Acid Acetylation Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Notch Signaling Pathway Nervous System Development Heart Development Skeletal Muscle Tissue Development Circadian Rhythm Organ Morphogenesis Viral Process N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Lung Development Positive Regulation Of Protein Binding Positive Regulation Of Type I Interferon Production Cellular Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Estrogen Positive Regulation By Host Of Viral Transcription Histone H4 Acetylation Histone H2B Acetylation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Regulation Of Tubulin Deacetylation Regulation Of Cellular Response To Heat
Pathways		PPARA activates gene expression Bile acid and bile salt metabolism Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Generic Transcription Pathway Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Transcriptional regulation of white adipocyte differentiation Biological oxidations Synthesis of bile acids and bile salts Orphan transporters Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Recycling of bile acids and salts Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) REV-ERBA represses gene expression Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Mitochondrial biogenesis Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression	Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by Wnt NOTCH2 intracellular domain regulates transcription Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Pre-NOTCH Transcription and Translation RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 in Cancer Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by NOTCH1 PEST Domain Mutants in Cancer Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants PPARA activates gene expression Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Attenuation phase G2/M Transition HATs acetylate histones RORA activates circadian gene expression HSF1-dependent transactivation TRAF3-dependent IRF activation pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Pre-NOTCH Expression and Processing Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Innate Immune System Fatty acid, triacylglycerol, and ketone body metabolism Cytosolic sensors of pathogen-associated DNA Cellular response to heat stress REV-ERBA represses gene expression Cell Cycle, Mitotic RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT TRAF6 mediated IRF7 activation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by WNT in cancer BMAL1:CLOCK,NPAS2 activates circadian gene expression Polo-like kinase mediated events
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Non-small cell lung cancer ( 23144319)	Crohn's disease ( 22936669)
Protein-Protein Interactions		63 interactors: ACTN2 AHR ANKRD11 AR ARNT BRCA1 CARM1 CCND3 CCNT1 CDK4 CREBBP CTNNB1 DDX17 DDX5 DLX2 DLX5 EID1 EP300 ESR1 ESR2 ESRRB ETV1 FOS GMEB1 HIF1A HIST3H3 HIST4H4 HNF4A JUN KIF5A KIF5B KIF5C MAGEA11 MEF2C NKX2-1 NR1I2 NR3C1 NR4A1 OPN1LW PIAS3 PML PPARA PPARD PPARG PPFIA1 PPFIA4 PRMT1 PSMB9 RARA RORA RXRA SLC30A9 SMARCE1 SRA1 SRCAP STAT6 SUMO1 TAF9 THRB TP53 TXNRD2 VDR YWHAH	344 interactors: ABL1 ACSM5 ACTA2 ACTB AHR AKT1 ALX1 APEX1 AR ARNT ARNTL ARSF ASCL1 ASH2L ATF5 ATR BAG6 BCAS2 BCL3 BCL6 BRCA1 BRMS1 C1R CALCOCO1 CARM1 CCNB1 CCND1 CDK1 CDK2 CDKN1A CDT1 CDX2 CEBPA CEBPB CEBPD CFH CHD4 CITED1 CITED2 CITED4 CLOCK CLTC CNOT4 CNTN2 COPS2 COPS6 CREB1 CREBBP CRX CTBP1 CTBP2 CTF1 CTNNB1 CXCL8 CXXC1 DAO DBP DDIT3 DDX24 DDX5 DECR2 DEK DTX1 E2F5 EGR1 EID1 EID2 ELF3 ELK1 EMB EPAS1 EPO ESR1 ESR2 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXL5 FEN1 FHL2 FOSB FOSL1 FOSL2 FOXO1 FOXO3 FOXP3 GAA GABPA GATA2 GATA4 GATA5 GATA6 GOLGA2 GPBP1 GPS2 GRB2 GRIP1 GTF2B HAND2 HBP1 HDAC1 HDAC3 HDAC6 HERC1 HIF1A HIPK2 HIST1H1A HIST1H1D HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A HIST2H2AB HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HMGN1 HMGN2 HNF1A HNRNPU HNRNPUL1 HOXA10 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD4 HPS6 HSP90AA2P IMMT ING1 ING2 ING4 ING5 IRF1 IRF2 IRF3 IRF5 IRF7 ITIH3 JDP2 JMY JUN JUNB JUND KAT2A KAT2B KAT5 KCTD5 KLF1 KLF13 KLF2 KLF4 KLF5 KPNA2 KRT18 LEF1 MAF MAGED1 MAML1 MAP2K1 MAP3K5 MAPK1 MAPK8 MAPT MAX MCM3AP MDC1 MDM2 MDM4 MEF2A MEF2C MEF2D MGMT MITF MN1 MPG MRE11A MSH6 MSTO1 MYB MYBL2 MYC MYOD1 N4BP2 NAP1L1 NAP1L4 NBN NCOA1 NCOA2 NCOA3 NCOA6 NEDD1 NEIL2 NEUROD1 NFATC1 NFATC2 NFKB1 NFYB NOTCH1 NOXA1 NPAS2 NPM1 NR1H4 NR2F2 NR4A1 NUP98 NUPR1 NUTM1 OLIG2 PAK2 PAX5 PAX6 PAX8 PAXIP1 PCK2 PCNA PDHX PELP1 PIAS3 PIN1 PLAGL1 PLG PLSCR1 PLSCR2 PML POLB POLD2 POU3F2 PPARA PPARD PPARG PPP2R5C PRKCA PRKCB PRKCD PROX1 PTMA RAD23A RAD50 RAN RB1 RBM14 RECQL4 REL RELA RORA RPL27 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX2 RUNX3 SATB1 SAV1 SENP3 SEPP1 SERTAD1 SET SETD1A SGCG SIRT1 SIRT2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SNIP1 SNW1 SOX9 SP1 SP3 SPHK1 SPIB SRC SREBF2 SRY SS18 SS18L1 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 SUB1 SUV39H1 TACC2 TADA3 TAF1B TAL1 TCF12 TCF3 TCF4 TCF7L2 TDG TERF2 TFAP2A TGFB1I1 TGS1 THPO TINAGL1 TNIP2 TP53 TP53BP1 TP63 TP73 TRAF2 TRERF1 TRIP4 TSG101 TWIST1 UBE2D1 UBE2I UBQLN1 USF2 VPS18 WDR59 WDR82 XRCC6 YY1 ZBTB16 ZBTB17 ZBTB48 ZBTB7B ZBTB8A ZC3H12A ZEB1 ZFPM2 ZNF148 ZNF76 ZRANB2
Entrez ID		10499	2033
HPRD ID		09066	04078
Ensembl ID		ENSG00000140396	ENSG00000100393
Uniprot IDs		Q15596	Q09472 Q7Z6C1
PDB IDs		1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF	1L3E 1P4Q 2K8F 3BIY 3I3J 3IO2 3P57 3T92 4BHW
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Steroid Hormone Mediated Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression DNA-templated Transcription, Initiation Gene Expression Hormone-mediated Signaling Pathway Positive Regulation Of Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Response To Steroid Hormone Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription, DNA-templated Response To Organic Cyclic Compound Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Response To Hormone Response To Lipid Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Organic Substance Anatomical Structure Development Developmental Process Multicellular Organismal Development Biosynthetic Process Cellular Response To Hormone Stimulus Cellular Response To Organic Substance	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Response To Organic Substance Cell Differentiation Regulation Of Cell Differentiation Developmental Process Regulation Of Cell Proliferation Anatomical Structure Development Multicellular Organismal Development Cellular Response To Organic Substance System Development Cellular Response To Stress Response To Stress Regulation Of Cellular Process Tissue Development
Tagcloud ?		bioenergy causally clearer clinicopathologies colonize coregulator coregulators decidual decidualization decidualize dovetailing endometriotic evade glycolytic launch minireview ncoa1 ncoa3 p160 pacemaker pathobiology pleiotropy proposal quiescence subfecundity tantalizing triad underexplored underpinning	ache ahr antimirs arguing cholinergic cns correlates creb detrusor influences jarid1a limits mecp2 micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Difference) ?		bioenergy causally clearer clinicopathologies colonize coregulator coregulators decidual decidualization decidualize dovetailing endometriotic evade glycolytic launch minireview ncoa1 ncoa3 p160 pacemaker pathobiology pleiotropy proposal quiescence subfecundity tantalizing triad underexplored underpinning	ache ahr antimirs arguing cholinergic cns correlates creb detrusor influences jarid1a limits mecp2 micrornas mimics mir mirna mirnas nuclei obstruction outlet outside plasticity pnkd referenced synapse transfection unrelated urethra
Tagcloud (Intersection) ?