ATP7A and ATOX1

Number of citations of the paper that reports this interaction (PMID 10557326)
47

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vivo)

		ATP7A	ATOX1
Gene Name		ATPase, Cu++ transporting, alpha polypeptide	antioxidant 1 copper chaperone
Image
Gene Ontology Annotations	Cellular Component	Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Brush Border Membrane Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Copper-exporting ATPase Activity Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding Superoxide Dismutase Copper Chaperone Activity Copper-dependent Protein Binding	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding
	Biological Process	Response To Reactive Oxygen Species Blood Vessel Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Regulation Of Oxidative Phosphorylation Tryptophan Metabolic Process Tyrosine Metabolic Process Catecholamine Metabolic Process Copper Ion Transport Cellular Copper Ion Homeostasis Mitochondrion Organization Lactation Locomotory Behavior Response To Iron(III) Ion Response To Zinc Ion Detoxification Of Copper Ion Regulation Of Gene Expression Copper Ion Import Plasma Membrane Copper Ion Transport Peptidyl-lysine Modification Removal Of Superoxide Radicals Cerebellar Purkinje Cell Differentiation Pyramidal Neuron Development Central Nervous System Neuron Development Extracellular Matrix Organization Collagen Fibril Organization Hair Follicle Morphogenesis Ion Transmembrane Transport T-helper Cell Differentiation Epinephrine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Norepinephrine Biosynthetic Process Serotonin Metabolic Process Positive Regulation Of Catalytic Activity Pigmentation Negative Regulation Of Neuron Apoptotic Process Skin Development ATP Metabolic Process Elastic Fiber Assembly Lung Alveolus Development Negative Regulation Of Metalloenzyme Activity Positive Regulation Of Metalloenzyme Activity Neuron Projection Morphogenesis Dendrite Morphogenesis Cartilage Development Positive Regulation Of Oxidoreductase Activity Elastin Biosynthetic Process Transmembrane Transport Copper Ion Export	Response To Reactive Oxygen Species Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress Intracellular Copper Ion Transport Copper Ion Transmembrane Transport
Pathways		Ion transport by P-type ATPases Ion channel transport Detoxification of Reactive Oxygen Species	Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ATOX1 CP PDZD11	6 interactors: ATP7A ATP7B C21orf2 FAM118A FKBP4 GGPS1
Entrez ID		538	475
HPRD ID		02054	03779
Ensembl ID		ENSG00000165240	ENSG00000177556
Uniprot IDs		B4DRW0 Q04656 Q762B6	O00244
PDB IDs		1AW0 1KVI 1KVJ 1Q8L 1S6O 1S6U 1Y3J 1Y3K 1YJR 1YJT 1YJU 1YJV 2AW0 2G9O 2GA7 2K1R 2KIJ 2KMV 2KMX 3CJK	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX
Enriched GO Terms of Interacting Partners?		Copper Ion Transport Transition Metal Ion Homeostasis Intracellular Copper Ion Transport Transmembrane Transport Ion Transport Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Copper Ion Transmembrane Transport Maintenance Of Cell Polarity Pantothenate Metabolic Process Biotin Metabolic Process Cellular Chemical Homeostasis Ion Homeostasis Cellular Copper Ion Homeostasis Cellular Homeostasis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Copper Ion Homeostasis Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Metal Ion Transport Chemical Homeostasis Cation Transport Ion Transmembrane Transport Transport Homeostatic Process Cellular Iron Ion Homeostasis Water-soluble Vitamin Metabolic Process Neurotransmitter Secretion Vitamin Metabolic Process Iron Ion Homeostasis Regulation Of Neurotransmitter Levels Protein Localization To Plasma Membrane Establishment Of Localization In Cell Neurotransmitter Transport Establishment Or Maintenance Of Cell Polarity Response To Reactive Oxygen Species Plasma Membrane Organization Cellular Localization	Copper Ion Transport Copper Ion Export Copper Ion Transmembrane Transport Copper Ion Import Cellular Copper Ion Homeostasis Copper Ion Homeostasis Response To Copper Ion Lactation Gland Development Body Fluid Secretion Elastin Biosynthetic Process Steroid Hormone Receptor Complex Assembly Plasma Membrane Copper Ion Transport Geranylgeranyl Diphosphate Biosynthetic Process Transition Metal Ion Homeostasis Geranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process Metal Ion Transport Mammary Gland Development Elastin Metabolic Process Detoxification Of Copper Ion Response To Iron(III) Ion Sequestering Of Calcium Ion Epinephrine Metabolic Process Intracellular Copper Ion Transport Farnesyl Diphosphate Metabolic Process Cation Transport Norepinephrine Biosynthetic Process Negative Regulation Of Metalloenzyme Activity Elastic Fiber Assembly Positive Regulation Of Metalloenzyme Activity Response To Metal Ion Regulation Of Oxidative Phosphorylation Sequestering Of Metal Ion Tyrosine Metabolic Process Pyramidal Neuron Development Pyramidal Neuron Differentiation Norepinephrine Metabolic Process Cellular Metal Ion Homeostasis Negative Regulation Of Microtubule Polymerization Cellular Zinc Ion Homeostasis Cerebellar Purkinje Cell Differentiation Serotonin Metabolic Process Cellular Cation Homeostasis Extracellular Matrix Assembly Cellular Ion Homeostasis Zinc Ion Homeostasis Cerebellar Purkinje Cell Layer Morphogenesis Ion Transport Metal Ion Homeostasis
Tagcloud ?		96h basolateral cd1 copper cuproenzyme deliver deprivation duodenum enterocytes grew iec influences irrespective kd ki67 menkes pcna perturbed proliferating pumping relate rodent shrna silenced slower transporting trigger unaltered unexpected	accumulated affects allowing chains chaperones chelated cisplatin compartments copper cu decays elucidation embryonic emission exist fibroblast hct nuclei nucleus optimizing owing positron radionuclide radiopharmaceuticals tomography traffic transport transporting upregulating
Tagcloud (Difference) ?		96h basolateral cd1 cuproenzyme deliver deprivation duodenum enterocytes grew iec influences irrespective kd ki67 menkes pcna perturbed proliferating pumping relate rodent shrna silenced slower trigger unaltered unexpected	accumulated affects allowing chains chaperones chelated cisplatin compartments cu decays elucidation embryonic emission exist fibroblast hct nuclei nucleus optimizing owing positron radionuclide radiopharmaceuticals tomography traffic transport upregulating
Tagcloud (Intersection) ?		copper transporting