ATP7A

Gene Name		ATPase, Cu++ transporting, alpha polypeptide
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Gene Ontology Annotations	Cellular Component	Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Brush Border Membrane Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Copper-exporting ATPase Activity Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding Superoxide Dismutase Copper Chaperone Activity Copper-dependent Protein Binding
	Biological Process	Response To Reactive Oxygen Species Blood Vessel Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Regulation Of Oxidative Phosphorylation Tryptophan Metabolic Process Tyrosine Metabolic Process Catecholamine Metabolic Process Copper Ion Transport Cellular Copper Ion Homeostasis Mitochondrion Organization Lactation Locomotory Behavior Response To Iron(III) Ion Response To Zinc Ion Detoxification Of Copper Ion Regulation Of Gene Expression Copper Ion Import Plasma Membrane Copper Ion Transport Peptidyl-lysine Modification Removal Of Superoxide Radicals Cerebellar Purkinje Cell Differentiation Pyramidal Neuron Development Central Nervous System Neuron Development Extracellular Matrix Organization Collagen Fibril Organization Hair Follicle Morphogenesis Ion Transmembrane Transport T-helper Cell Differentiation Epinephrine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Norepinephrine Biosynthetic Process Serotonin Metabolic Process Positive Regulation Of Catalytic Activity Pigmentation Negative Regulation Of Neuron Apoptotic Process Skin Development ATP Metabolic Process Elastic Fiber Assembly Lung Alveolus Development Negative Regulation Of Metalloenzyme Activity Positive Regulation Of Metalloenzyme Activity Neuron Projection Morphogenesis Dendrite Morphogenesis Cartilage Development Positive Regulation Of Oxidoreductase Activity Elastin Biosynthetic Process Transmembrane Transport Copper Ion Export
Pathways		Ion transport by P-type ATPases Ion channel transport Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: ATOX1 CP PDZD11
Entrez ID		538
HPRD ID		02054
Ensembl ID		ENSG00000165240
Uniprot IDs		B4DRW0 Q04656 Q762B6
PDB IDs		1AW0 1KVI 1KVJ 1Q8L 1S6O 1S6U 1Y3J 1Y3K 1YJR 1YJT 1YJU 1YJV 2AW0 2G9O 2GA7 2K1R 2KIJ 2KMV 2KMX 3CJK
Enriched GO Terms of Interacting Partners?		Copper Ion Transport Transition Metal Ion Homeostasis Intracellular Copper Ion Transport Transmembrane Transport Ion Transport Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Copper Ion Transmembrane Transport Maintenance Of Cell Polarity Pantothenate Metabolic Process Biotin Metabolic Process Cellular Chemical Homeostasis Ion Homeostasis Cellular Copper Ion Homeostasis Cellular Homeostasis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Copper Ion Homeostasis Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Metal Ion Transport Chemical Homeostasis Cation Transport Ion Transmembrane Transport Transport Homeostatic Process Cellular Iron Ion Homeostasis Water-soluble Vitamin Metabolic Process Neurotransmitter Secretion Vitamin Metabolic Process Iron Ion Homeostasis Regulation Of Neurotransmitter Levels Protein Localization To Plasma Membrane Establishment Of Localization In Cell Neurotransmitter Transport Establishment Or Maintenance Of Cell Polarity Response To Reactive Oxygen Species Plasma Membrane Organization Cellular Localization
Tagcloud ?		96h basolateral cd1 copper cuproenzyme deliver deprivation duodenum enterocytes grew iec influences irrespective kd ki67 menkes pcna perturbed proliferating pumping relate rodent shrna silenced slower transporting trigger unaltered unexpected