ATP7A and CP

Number of citations of the paper that reports this interaction (PMID 11040994)
0

Data Source:
HPRD (in vitro)

		ATP7A	CP
Gene Name		ATPase, Cu++ transporting, alpha polypeptide	ceruloplasmin (ferroxidase)
Image
Gene Ontology Annotations	Cellular Component	Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Brush Border Membrane Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Lysosomal Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Copper-exporting ATPase Activity Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding Superoxide Dismutase Copper Chaperone Activity Copper-dependent Protein Binding	Ferroxidase Activity Copper Ion Binding Chaperone Binding
	Biological Process	Response To Reactive Oxygen Species Blood Vessel Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Regulation Of Oxidative Phosphorylation Tryptophan Metabolic Process Tyrosine Metabolic Process Catecholamine Metabolic Process Copper Ion Transport Cellular Copper Ion Homeostasis Mitochondrion Organization Lactation Locomotory Behavior Response To Iron(III) Ion Response To Zinc Ion Detoxification Of Copper Ion Regulation Of Gene Expression Copper Ion Import Plasma Membrane Copper Ion Transport Peptidyl-lysine Modification Removal Of Superoxide Radicals Cerebellar Purkinje Cell Differentiation Pyramidal Neuron Development Central Nervous System Neuron Development Extracellular Matrix Organization Collagen Fibril Organization Hair Follicle Morphogenesis Ion Transmembrane Transport T-helper Cell Differentiation Epinephrine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Norepinephrine Biosynthetic Process Serotonin Metabolic Process Positive Regulation Of Catalytic Activity Pigmentation Negative Regulation Of Neuron Apoptotic Process Skin Development ATP Metabolic Process Elastic Fiber Assembly Lung Alveolus Development Negative Regulation Of Metalloenzyme Activity Positive Regulation Of Metalloenzyme Activity Neuron Projection Morphogenesis Dendrite Morphogenesis Cartilage Development Positive Regulation Of Oxidoreductase Activity Elastin Biosynthetic Process Transmembrane Transport Copper Ion Export	Copper Ion Transport Cellular Iron Ion Homeostasis Transmembrane Transport Oxidation-reduction Process
Pathways		Ion transport by P-type ATPases Ion channel transport Detoxification of Reactive Oxygen Species	Metal ion SLC transporters Iron uptake and transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport
Drugs			Drotrecogin alfa
Diseases
GWAS			Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		3 interactors: ATOX1 CP PDZD11	8 interactors: ATP7A BTRC GAST LTF MPO PLG PROC UBC
Entrez ID		538	1356
HPRD ID		02054	00317
Ensembl ID		ENSG00000165240	ENSG00000047457
Uniprot IDs		B4DRW0 Q04656 Q762B6	A5PL27 P00450
PDB IDs		1AW0 1KVI 1KVJ 1Q8L 1S6O 1S6U 1Y3J 1Y3K 1YJR 1YJT 1YJU 1YJV 2AW0 2G9O 2GA7 2K1R 2KIJ 2KMV 2KMX 3CJK	1KCW 2J5W 4EJX 4ENZ
Enriched GO Terms of Interacting Partners?		Copper Ion Transport Transition Metal Ion Homeostasis Intracellular Copper Ion Transport Transmembrane Transport Ion Transport Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Copper Ion Transmembrane Transport Maintenance Of Cell Polarity Pantothenate Metabolic Process Biotin Metabolic Process Cellular Chemical Homeostasis Ion Homeostasis Cellular Copper Ion Homeostasis Cellular Homeostasis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Copper Ion Homeostasis Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Metal Ion Transport Chemical Homeostasis Cation Transport Ion Transmembrane Transport Transport Homeostatic Process Cellular Iron Ion Homeostasis Water-soluble Vitamin Metabolic Process Neurotransmitter Secretion Vitamin Metabolic Process Iron Ion Homeostasis Regulation Of Neurotransmitter Levels Protein Localization To Plasma Membrane Establishment Of Localization In Cell Neurotransmitter Transport Establishment Or Maintenance Of Cell Polarity Response To Reactive Oxygen Species Plasma Membrane Organization Cellular Localization	Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Immune System Process Removal Of Superoxide Radicals Cellular Response To Superoxide Response To Superoxide Defense Response To Fungus Response To Oxygen Radical Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteolysis Regulation Of Cell Death Response To Fungus Superoxide Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Response To Stress Negative Regulation Of Wound Healing Response To Stimulus Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Iron Assimilation By Chelation And Transport Hypochlorous Acid Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Elastin Biosynthetic Process Plasma Membrane Copper Ion Transport Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Blood Coagulation Cellular Response To Reactive Oxygen Species Reactive Oxygen Species Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Tissue Remodeling Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Antifungal Humoral Response Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Chondrocyte Proliferation Copper Ion Export Negative Regulation Of Osteoclast Development Response To Gold Nanoparticle Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Body Fluid Levels
Tagcloud ?		96h basolateral cd1 copper cuproenzyme deliver deprivation duodenum enterocytes grew iec influences irrespective kd ki67 menkes pcna perturbed proliferating pumping relate rodent shrna silenced slower transporting trigger unaltered unexpected	airways anesthetized artificially attacks breaths bronchoconstriction citric clarified counteracts endogenously gastroesophageal guinea halved hoe implication inhalation inhaled micromol nerves nk1 nk2 nmma reflux rl sr submaximum tachykinin tachykinins ventilated
Tagcloud (Difference) ?		96h basolateral cd1 copper cuproenzyme deliver deprivation duodenum enterocytes grew iec influences irrespective kd ki67 menkes pcna perturbed proliferating pumping relate rodent shrna silenced slower transporting trigger unaltered unexpected	airways anesthetized artificially attacks breaths bronchoconstriction citric clarified counteracts endogenously gastroesophageal guinea halved hoe implication inhalation inhaled micromol nerves nk1 nk2 nmma reflux rl sr submaximum tachykinin tachykinins ventilated
Tagcloud (Intersection) ?