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TMEM45B and TREX1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
TMEM45B
TREX1
Description
transmembrane protein 45B
three prime repair exonuclease 1
Image
No pdb structure
GO Annotations
Cellular Component
Lysosome
Lysosomal Membrane
Endosome
Golgi Apparatus
Trans-Golgi Network
Endosome Membrane
Membrane
Nucleus
Nuclear Envelope
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Oligosaccharyltransferase Complex
Membrane
Protein-DNA Complex
Nuclear Replication Fork
Molecular Function
Protein Binding
Magnesium Ion Binding
Nucleic Acid Binding
DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Nuclease Activity
Exonuclease Activity
DNA Exonuclease Activity
Protein Binding
3'-5'-DNA Exonuclease Activity
DNA Binding, Bending
Double-stranded DNA 3'-5' DNA Exonuclease Activity
3'-5' Exonuclease Activity
Hydrolase Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Adenyl Deoxyribonucleotide Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
WW Domain Binding
Biological Process
Immune System Process
Innate Immune Response
Response To Pain
DNA Damage Checkpoint Signaling
Blood Vessel Development
Kidney Development
Adaptive Immune Response
Organ Or Tissue Specific Immune Response
Activation Of Immune Response
Macrophage Activation Involved In Immune Response
Lymphoid Progenitor Cell Differentiation
Immune Response In Brain Or Nervous System
Inflammatory Response To Antigenic Stimulus
T Cell Antigen Processing And Presentation
Regulation Of Immunoglobulin Production
Heart Morphogenesis
Heart Process
Atrial Cardiac Muscle Tissue Development
Generation Of Precursor Metabolites And Energy
Regulation Of Glycolytic Process
DNA Metabolic Process
DNA Replication
DNA Repair
Mismatch Repair
DNA Modification
DNA Catabolic Process
DNA Recombination
Inflammatory Response
Immune Response
DNA Damage Response
Determination Of Adult Lifespan
Response To UV
Regulation Of Gene Expression
Regulation Of Fatty Acid Metabolic Process
Regulation Of Metabolic Process
Mitotic G1 DNA Damage Checkpoint Signaling
Retrotransposition
Regulation Of Type I Interferon Production
Regulation Of Tumor Necrosis Factor Production
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Cellular Response To UV
Cellular Response To Interferon-beta
Apoptotic Cell Clearance
Regulation Of Cellular Respiration
Innate Immune Response
Regulation Of Innate Immune Response
Establishment Of Protein Localization
Negative Regulation Of Innate Immune Response
Regulation Of Lipid Biosynthetic Process
Regulation Of Inflammatory Response
Protein Stabilization
Regulation Of T Cell Activation
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Protein Complex Stability
Cellular Response To Type I Interferon
Cellular Response To Gamma Radiation
Cellular Response To Hydroxyurea
Immune Complex Formation
CGAS/STING Signaling Pathway
Negative Regulation Of CGAS/STING Signaling Pathway
DNA Synthesis Involved In UV-damage Excision Repair
Regulation Of Lysosome Organization
Pathways
Regulation by TREX1
IRF3-mediated induction of type I IFN
Drugs
Diseases
Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE)
Aicardi-Goutieres Syndrome (AGS)
Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS
Breast cancer (
22383897
)
Night sleep phenotypes (
27126917
)
Obesity-related traits (
23251661
)
Obsessive-compulsive traits (
33531474
)
Serum metabolite levels (
33031748
)
Spontaneous preterm birth with premature rupture of membranes (
31194736
)
Type 2 diabetes (
22238593
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Obesity-related traits (
23251661
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Interacting Genes
41 interacting genes:
ANKRD46
APOD
APOL2
AQP1
ARLN
BMP10
C3orf52
CACNG1
CDS2
CYB561D2
DOLK
FAM3C
FKBP8
GIMAP1
INSIG2
LAT
NSG1
PLN
PLP1
PLPP4
SEC22A
SEC23A
SMAGP
SMIM1
SNORC
SYNGR1
TINAG
TMEM128
TMEM218
TMEM229B
TMEM243
TMEM254
TMEM60
TMEM97
TNFRSF10C
TREX1
TSPAN33
UBE2G2
UPK1B
VAMP5
VKORC1
48 interacting genes:
AQP6
ATM
ATR
CD81
CHCHD2
CLDN22
CRB3
CYB561
CYSRT1
EBP
ELOVL4
ERGIC3
FAM174A
FAM209A
FFAR3
FNDC9
GJA5
GKN1
GPR42
HSD17B13
IFNGR2
IFT20
JAGN1
KRTAP10-7
MCM7
MSH2
NBN
PEX12
PRKDC
PRND
RELL1
RIBC2
RNASEK
RPA1
SEC11C
SET
SLC10A6
SLC22A2
SLC71A2
SLC7A14
TM4SF18
TMEM205
TMEM207
TMEM45B
TMEM86B
TMX2
UBQLN1
VKORC1
Entrez ID
120224
11277
HPRD ID
14020
09423
Ensembl ID
ENSG00000151715
ENSG00000213689
Uniprot IDs
Q96B21
Q5TZT0
Q9NSU2
PDB IDs
7TQN
7TQO
7TQP
7TQQ
8VL7
9AVA
Enriched GO Terms of Interacting Partners
?
Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Histone H2AXS139 Kinase Activity
Membrane
Chromosome, Telomeric Region
Protein Localization To Site Of Double-strand Break
Double-strand Break Repair
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Somatic Cell DNA Recombination
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Telomere Maintenance
DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
DNA-dependent Protein Kinase Activity
Telomere Organization
Double-strand Break Repair Via Homologous Recombination
Mitotic DNA Damage Checkpoint Signaling
Recombinational Repair
DNA Recombination
Mitotic DNA Integrity Checkpoint Signaling
Signal Transduction In Response To DNA Damage
Somatic Recombination Of Immunoglobulin Gene Segments
Protein Binding
MutLalpha Complex Binding
Negative Regulation Of Telomere Capping
Somatic Diversification Of Immunoglobulins
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Negative Regulation Of Mitotic Cell Cycle
Protein Localization To Organelle
Chromosome Organization
Negative Regulation Of Cell Cycle Phase Transition
Response To Gamma Radiation
Mitotic G2/M Transition Checkpoint
DNA Repair
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Telomere Capping
Response To Ionizing Radiation
Regulation Of Double-strand Break Repair
Replicative Senescence
Regulation Of Cellular Response To Heat
DNA Replication
Endoplasmic Reticulum
Damaged DNA Binding
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of DNA-templated DNA Replication Initiation
DNA Metabolic Process
Negative Regulation Of Cell Cycle Process
Pexophagy
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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