DACH2 and IRF9

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		DACH2	IRF9
Description		dachshund family transcription factor 2	interferon regulatory factor 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol ISGF3 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Development Of Primary Female Sexual Characteristics	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus
Pathways			Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Childhood ear infection ( 27182965) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: CFTR IRF9 KAT2B TSC1	20 interacting genes: ARID3B DACH2 DMRTC2 HOXC9 IFNA1 ILF3 IRF1 IRF2BP1 MYO1F NFKB1 NR2E3 POU2F1 RELA S100A13 STAT1 STAT2 TLX2 TLX3 TOP1 VENTX
Entrez ID		117154	10379
HPRD ID		06481	00960
Ensembl ID		ENSG00000126733	ENSG00000213928
Uniprot IDs		A8K3I1 Q96NX9	A0A8V8TMJ8 A0A8V8TP83 H0YNP4 Q00978
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding Positive Regulation Of Anion Channel Activity Protein-containing Complex Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Memory T Cell Differentiation TSC1-TSC2 Complex Response To Insulin Negative Regulation Of RRNA Processing N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Histone H3K9 Acetyltransferase Activity ISGF3 Complex Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Response To Stress Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Learning Or Memory Response To Peptide Hormone ATPase Inhibitor Activity Cellular Response To Nutrient Levels Negative Regulation Of Centriole Replication Internal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Ribosome Biogenesis Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Negative Regulation Of Ribosome Biogenesis Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Histone H3 Acetyltransferase Activity Amelogenesis Cognition Negative Regulation Of Cell Size Regulation Of Transcription By Glucose ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Internal Protein Amino Acid Acetylation Actomyosin Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore	DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Virus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Defense Response To Virus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process NF-kappaB P50/p65 Complex Interferon-mediated Signaling Pathway RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm ISGF3 Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Response To Peptide Hormone Transcription Coactivator Binding Type I Interferon-mediated Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nicotine Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Interleukin-12 Production Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Mechanical Stimulus Actinin Binding DNA-templated Transcription Type II Interferon-mediated Signaling Pathway
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