TM4SF19 and ATP6V0B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TM4SF19	ATP6V0B
Description		transmembrane 4 L six family member 19	ATPase H+ transporting V0 subunit b
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytoskeleton Actin Cytoskeleton Membrane Filopodium Cell Projection	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Protein Binding Protein Homodimerization Activity	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Positive Regulation Of Osteoclast Differentiation	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Tiludronic acid
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		39 interacting genes: ABHD16A ARLN ATP6V0B BNIP1 C14orf180 CCDC167 CD79A CRK CTXN3 CYBC1 CYP4F2 DAPP1 ERG28 GET1 GIMAP1 GIMAP5 GOSR2 GPR152 HMOX1 NDUFA3 PLP2 PMP22 RIN3 SEC22B SERP2 SMIM1 STAT3 STX7 SYS1 TMEM167B TMEM179B TMEM237 TMEM42 TNS2 TSNARE1 UBE2J1 VAMP3 VAMP4 ZFPL1	28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG
Entrez ID		116211	533
HPRD ID		14013	04759
Ensembl ID		ENSG00000145107	ENSG00000117410
Uniprot IDs		B7ZW46 Q96DZ7	E9PNL3 Q99437
PDB IDs			6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex Endoplasmic Reticulum Membrane Organelle Fusion Membrane Fusion Organelle Membrane Fusion Endoplasmic Reticulum Vesicle-mediated Transport Golgi Vesicle Transport Vesicle Fusion Golgi To Plasma Membrane Protein Transport Transport Vesicle Establishment Of Protein Localization To Plasma Membrane Vesicle Docking SNARE Complex Assembly Golgi To Plasma Membrane Transport SNARE Binding Golgi Membrane Endocytic Vesicle Membrane Organization Vesicle Organization Organelle Localization By Membrane Tethering Phagocytic Vesicle Membrane Protein Binding Membrane Docking	Membrane Specific Granule Membrane Gap Junction-mediated Intercellular Transport Protein Sequestering Activity Intercellular Transport
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