LTN1 and TMEM173

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		LTN1	TMEM173
Gene Name		listerin E3 ubiquitin protein ligase 1	transmembrane protein 173
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding
	Biological Process	Protein Autoubiquitination	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Positive Regulation Of Transcription Factor Import Into Nucleus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Cellular Response To Exogenous DsRNA
Pathways			Regulation of innate immune responses to cytosolic DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		6 interactors: HES4 IRF7 TIRAP TMEM173 UBC UBE2D2	9 interactors: CCDC47 DDOST IRAK1 LTN1 MBOAT7 SGPL1 STT3A SURF4 TRIM32
Entrez ID		26046	340061
HPRD ID		10327	14173
Ensembl ID		ENSG00000198862
Uniprot IDs		O94822	Q86WV6
PDB IDs			4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI
Enriched GO Terms of Interacting Partners?		Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Immune Response Interferon-beta Production Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Regulation Of Cytokine Production Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune System Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Interferon-beta Production Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Regulation Of Nitrogen Compound Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Protein Binding MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels
Tagcloud ?		abce1 aberrant codons decay dom34 drosophila e3 eliminate encounter erf1 eukaryotic homolog ligase machineries mrnas nonstop nsd polypeptide proteasome recycling rescue ribosome ribosomes rqc stop translational triggered triggering uncovered	advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish
Tagcloud (Difference) ?		abce1 aberrant codons decay dom34 drosophila e3 eliminate encounter erf1 eukaryotic homolog ligase machineries mrnas nonstop nsd polypeptide proteasome recycling rescue ribosome ribosomes rqc stop translational triggered triggering uncovered	advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish
Tagcloud (Intersection) ?