LTN1 and HES4

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		LTN1	HES4
Description		listerin E3 ubiquitin protein ligase 1	hes family bHLH transcription factor 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytosolic Ribosome RQC Complex	Chromatin Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ribosomal Large Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity
	Biological Process	Protein Ubiquitination Protein Autoubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Anterior/posterior Pattern Specification Cell Differentiation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference ( 28552196) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration in psychotic disorders ( 29064472) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	HDL cholesterol levels ( 32203549)
Interacting Genes		9 interacting genes: AGO1 HES4 IRF7 STING1 TIRAP UBC UBE2D1 UBE2D2 UBE2L3	5 interacting genes: COPG2 LTN1 PCBD1 PCBD2 RGS3
Entrez ID		26046	57801
HPRD ID		10327	16273
Ensembl ID		ENSG00000198862	ENSG00000188290
Uniprot IDs		O94822	D6REB3 E9PB28 Q9HCC6
PDB IDs		3J92
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Regulation Of Interferon-beta Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon Production Post-translational Protein Modification Regulation Of RNA Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Nucleoplasm Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Activation Of Innate Immune Response Catabolic Process Protein Ubiquitination Proteolysis Modification-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Innate Immune Response Regulation Of RNA Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Transcription Coactivator Activity Positive Regulation Of Ribosome Biogenesis Positive Regulation Of Pattern Recognition Receptor Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-15 Production Cyclic-di-GMP Binding STING Complex Positive Regulation Of Response To Cytokine Stimulus Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Immune Response-activating Signaling Pathway Signaling Adaptor Activity Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Primary Metabolic Process Establishment Of Viral Latency Regulation Of Transcription By RNA Polymerase II Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway 2',3'-cyclic GMP-AMP Binding Positive Regulation Of Type I Interferon Production Protein Modification Process	4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tetrahydrobiopterin Biosynthetic Process Tetrahydrobiopterin Metabolic Process Pteridine-containing Compound Biosynthetic Process Diol Metabolic Process Pteridine-containing Compound Metabolic Process Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Lyase Activity RQC Complex Alcohol Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Ribosomal Large Subunit Binding COPI-coated Vesicle COPI Vesicle Coat Tyrosine Metabolic Process COPI-coated Vesicle Membrane Bounding Membrane Of Organelle Small Molecule Biosynthetic Process
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