LTN1 and HES4

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		LTN1	HES4
Gene Name		listerin E3 ubiquitin protein ligase 1	hes family bHLH transcription factor 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	DNA Binding Transcription Factor Binding Protein Dimerization Activity
	Biological Process	Protein Autoubiquitination	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nervous System Development Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: HES4 IRF7 TIRAP TMEM173 UBC UBE2D2	5 interactors: COPG2 LTN1 PCBD1 PCBD2 RGS3
Entrez ID		26046	57801
HPRD ID		10327	16273
Ensembl ID		ENSG00000198862	ENSG00000188290
Uniprot IDs		O94822	D6REB3 E9PB28 Q9HCC6
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Immune Response Interferon-beta Production Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Regulation Of Cytokine Production Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune System Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Interferon-beta Production Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Regulation Of Nitrogen Compound Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Protein Binding MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels	Tetrahydrobiopterin Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Pteridine-containing Compound Metabolic Process Protein Homotetramerization Protein Tetramerization Protein Heterooligomerization Coenzyme Biosynthetic Process Protein Homooligomerization Cofactor Metabolic Process L-phenylalanine Catabolic Process L-phenylalanine Metabolic Process Protein Oligomerization Regulation Of Protein Homodimerization Activity
Tagcloud ?		abce1 aberrant codons decay dom34 drosophila e3 eliminate encounter erf1 eukaryotic homolog ligase machineries mrnas nonstop nsd polypeptide proteasome recycling rescue ribosome ribosomes rqc stop translational triggered triggering uncovered	brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration pdia6 prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Difference) ?		abce1 aberrant codons decay dom34 drosophila e3 eliminate encounter erf1 eukaryotic homolog ligase machineries mrnas nonstop nsd polypeptide proteasome recycling rescue ribosome ribosomes rqc stop translational triggered triggering uncovered	brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration pdia6 prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Intersection) ?