CHRNB2 and CHRNA4

Number of citations of the paper that reports this interaction (PMID 15944128)
68

Data Source:
HPRD (in vivo)

		CHRNB2	CHRNA4
Gene Name		cholinergic receptor, nicotinic, beta 2 (neuronal)	cholinergic receptor, nicotinic, alpha 4 (neuronal)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Integral Component Of Membrane Cell Junction Postsynaptic Membrane	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Cell Junction Dendrite Neuronal Cell Body Postsynaptic Membrane
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Drug Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding Protein Heterodimerization Activity	Acetylcholine-activated Cation-selective Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding
	Biological Process	Action Potential Conditioned Taste Aversion Response To Hypoxia Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Neurological System Process Cognition Protein Heterooligomerization Membrane Depolarization Regulation Of Synapse Assembly Synaptic Transmission Involved In Micturition Cation Transmembrane Transport	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Respiratory Gaseous Exchange Locomotory Behavior Regulation Of Dopamine Secretion Sensory Perception Of Pain Response To Nicotine Behavioral Response To Nicotine Exploration Behavior B Cell Activation Regulation Of Membrane Potential Neurological System Process Cognition Membrane Depolarization Regulation Of Inhibitory Postsynaptic Membrane Potential Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs		Nicotine Galantamine	Nicotine Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Galantamine Primidone Methylphenobarbital Phenobarbital Varenicline Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative
Diseases
GWAS			Chronic obstructive pulmonary disease ( 19300482)
Protein-Protein Interactions		3 interactors: CHRNA2 CHRNA4 CRELD2	7 interactors: CHRNB2 CHRNB4 CRELD2 CSNK2B UBQLN1 VSNL1 YWHAH
Entrez ID		1141	1137
HPRD ID		00335	00333
Ensembl ID		ENSG00000160716	ENSG00000101204
Uniprot IDs		P17787 Q5SXY3	B4DK78 P43681 Q4VAQ3 Q4VAQ5 Q59FV0
PDB IDs		2GVT 2K58 2K59 2KSR 2LM2	2GVT 2LLY
Enriched GO Terms of Interacting Partners?		Behavioral Response To Nicotine Synaptic Transmission Synaptic Transmission, Cholinergic Regulation Of Inhibitory Postsynaptic Membrane Potential Cell-cell Signaling Cation Transmembrane Transport Regulation Of Dopamine Secretion Exploration Behavior Cation Transport Membrane Hyperpolarization Ion Transmembrane Transport Response To Nicotine Respiratory Gaseous Exchange Transmembrane Transport Ion Transport Regulation Of Postsynaptic Membrane Potential Action Potential Sensory Perception Of Pain Membrane Depolarization Protein Heterooligomerization Regulation Of Anion Transport Response To Alkaloid B Cell Activation Adult Behavior	Synaptic Transmission Involved In Micturition Micturition Action Potential Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Membrane Potential Response To Nicotine Regulation Of Synaptic Transmission Excretion Neural Nucleus Development Smooth Muscle Contraction Regulation Of Dendrite Morphogenesis Regulation Of Signaling Renal System Process Lateral Geniculate Nucleus Development Glucocorticoid Catabolic Process Regulation Of Dendrite Development Membrane Depolarization Cellular Response To Stimulus Response To Alkaloid Adult Behavior Negative Regulation Of Action Potential Muscle Contraction Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Locomotory Behavior Regulation Of Cellular Localization Conditioned Taste Aversion Response To Stimulus Muscle System Process Positive Regulation Of Activin Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Dendrite Morphogenesis Response To Hypoxia Vestibulocochlear Nerve Development Positive Regulation Of Synaptic Transmission, Dopaminergic Optic Nerve Morphogenesis Signal Transduction Endothelial Tube Morphogenesis Positive Regulation Of Catecholamine Secretion Optic Nerve Development Signaling Regulation Of Neuron Projection Development Thalamus Development Cell Communication Negative Regulation Of Dendrite Development Glucocorticoid Metabolic Process
Tagcloud ?		300ppm aminobutyric biotin cholinergic dentate deoxynucleotidyl dutp ergic fimbria gabaergic hexachlorophene hilus inputs interneuron interneurons intramyelinic myelin neurogenesis nick nicotinic offspring pnd punctate reelin reversibly septal sgz subgranular vacuolation	adrenal axis bcl1 beck besides carriers cc cholinergic depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing
Tagcloud (Difference) ?		300ppm aminobutyric biotin dentate deoxynucleotidyl dutp ergic fimbria gabaergic hexachlorophene hilus inputs interneuron interneurons intramyelinic myelin neurogenesis nick nicotinic offspring pnd punctate reelin reversibly septal sgz subgranular vacuolation	adrenal axis bcl1 beck besides carriers cc depression depressiveness disruption epistasis genetics genotyped glucocorticoid glucocorticoids homozygous hypothalamic impacts inventory locus means nr3c1 pituitary polymorphisms reactivity rs1044396 rs41423247 showing
Tagcloud (Intersection) ?		cholinergic