CHRNB2 and CRELD2

Number of citations of the paper that reports this interaction (PMID 16238698)
7

Data Source:
HPRD (two hybrid)

		CHRNB2	CRELD2
Gene Name		cholinergic receptor, nicotinic, beta 2 (neuronal)	cysteine-rich with EGF-like domains 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Integral Component Of Membrane Cell Junction Postsynaptic Membrane	Extracellular Space Endoplasmic Reticulum Golgi Apparatus
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Drug Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding Protein Heterodimerization Activity	Calcium Ion Binding Protein Binding
	Biological Process	Action Potential Conditioned Taste Aversion Response To Hypoxia Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Neurological System Process Cognition Protein Heterooligomerization Membrane Depolarization Regulation Of Synapse Assembly Synaptic Transmission Involved In Micturition Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs		Nicotine Galantamine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CHRNA2 CHRNA4 CRELD2	6 interactors: C8orf33 CDKN2A CHRNA4 CHRNB2 MEST SUV39H1
Entrez ID		1141	79174
HPRD ID		00335	08455
Ensembl ID		ENSG00000160716	ENSG00000184164
Uniprot IDs		P17787 Q5SXY3	Q6UXH1
PDB IDs		2GVT 2K58 2K59 2KSR 2LM2
Enriched GO Terms of Interacting Partners?		Behavioral Response To Nicotine Synaptic Transmission Synaptic Transmission, Cholinergic Regulation Of Inhibitory Postsynaptic Membrane Potential Cell-cell Signaling Cation Transmembrane Transport Regulation Of Dopamine Secretion Exploration Behavior Cation Transport Membrane Hyperpolarization Ion Transmembrane Transport Response To Nicotine Respiratory Gaseous Exchange Transmembrane Transport Ion Transport Regulation Of Postsynaptic Membrane Potential Action Potential Sensory Perception Of Pain Membrane Depolarization Protein Heterooligomerization Regulation Of Anion Transport Response To Alkaloid B Cell Activation Adult Behavior	Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Response To Hypoxia Response To Nicotine Regulation Of B Cell Proliferation Action Potential Sensory Perception Of Pain Regulation Of Circadian Rhythm Lateral Geniculate Nucleus Development Membrane Depolarization RRNA Processing RRNA Metabolic Process Regulation Of Anion Transport Response To Alkaloid B Cell Activation Adult Behavior Senescence-associated Heterochromatin Focus Assembly Synaptic Transmission Involved In Micturition Ribosome Biogenesis Regulation Of Cellular Localization Negative Regulation Of Action Potential Positive Regulation Of Cellular Senescence Response To Abiotic Stimulus Locomotory Behavior Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Regulation Of Membrane Potential Negative Regulation Of Immature T Cell Proliferation In Thymus Histone H3-K9 Dimethylation Micturition Conditioned Taste Aversion Cognition Positive Regulation Of Macrophage Apoptotic Process Calcium Ion Transport Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Cell Aging Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Ribonucleoprotein Complex Biogenesis Vestibulocochlear Nerve Development Positive Regulation Of Synaptic Transmission, Dopaminergic Response To Stress Optic Nerve Morphogenesis Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Histone H3-K9 Trimethylation Positive Regulation Of Catecholamine Secretion Cellular Response To Stress Heterochromatin Assembly
Tagcloud ?		300ppm aminobutyric biotin cholinergic dentate deoxynucleotidyl dutp ergic fimbria gabaergic hexachlorophene hilus inputs interneuron interneurons intramyelinic myelin neurogenesis nick nicotinic offspring pnd punctate reelin reversibly septal sgz subgranular vacuolation	acidification apparatus atpase atpases baf bafilomycin bapta barely bfa brefeldin chelator cma concanamycin cos7 egfp grp78 hek293 intravesicular ionophore isomerase organelles pdi perturbation perturbed relying secretion secretory transportation vacuolar
Tagcloud (Difference) ?		300ppm aminobutyric biotin cholinergic dentate deoxynucleotidyl dutp ergic fimbria gabaergic hexachlorophene hilus inputs interneuron interneurons intramyelinic myelin neurogenesis nick nicotinic offspring pnd punctate reelin reversibly septal sgz subgranular vacuolation	acidification apparatus atpase atpases baf bafilomycin bapta barely bfa brefeldin chelator cma concanamycin cos7 egfp grp78 hek293 intravesicular ionophore isomerase organelles pdi perturbation perturbed relying secretion secretory transportation vacuolar
Tagcloud (Intersection) ?