CHRNB2 and CHRNA2

Number of citations of the paper that reports this interaction (PMID 8906617)
9

Data Source:
HPRD (in vivo)

		CHRNB2	CHRNA2
Gene Name		cholinergic receptor, nicotinic, beta 2 (neuronal)	cholinergic receptor, nicotinic, alpha 2 (neuronal)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Integral Component Of Membrane Cell Junction Postsynaptic Membrane	Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Cell Junction Postsynaptic Membrane
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Drug Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding Protein Heterodimerization Activity	Acetylcholine-activated Cation-selective Channel Activity Drug Binding Acetylcholine Receptor Activity Acetylcholine Binding
	Biological Process	Action Potential Conditioned Taste Aversion Response To Hypoxia Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Neurological System Process Cognition Protein Heterooligomerization Membrane Depolarization Regulation Of Synapse Assembly Synaptic Transmission Involved In Micturition Cation Transmembrane Transport	Ion Transport Cation Transport Signal Transduction Synaptic Transmission Protein Heterooligomerization Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Activation of Nicotinic Acetylcholine Receptors Postsynaptic nicotinic acetylcholine receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs		Nicotine Galantamine	Nicotine Carbachol Metocurine Iodide Gallamine Triethiodide Dextromethorphan Cisatracurium Besylate Mecamylamine Galantamine Procaine Rocuronium Atracurium Biperiden Doxacurium chloride Tubocurarine Mivacurium Decamethonium Metocurine Pancuronium Pipecuronium Vecuronium
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CHRNA2 CHRNA4 CRELD2	2 interactors: CHRNB2 CHRNB4
Entrez ID		1141	1135
HPRD ID		00335	00332
Ensembl ID		ENSG00000160716	ENSG00000120903
Uniprot IDs		P17787 Q5SXY3	B4DK19 J3KMY9 Q15822
PDB IDs		2GVT 2K58 2K59 2KSR 2LM2
Enriched GO Terms of Interacting Partners?		Behavioral Response To Nicotine Synaptic Transmission Synaptic Transmission, Cholinergic Regulation Of Inhibitory Postsynaptic Membrane Potential Cell-cell Signaling Cation Transmembrane Transport Regulation Of Dopamine Secretion Exploration Behavior Cation Transport Membrane Hyperpolarization Ion Transmembrane Transport Response To Nicotine Respiratory Gaseous Exchange Transmembrane Transport Ion Transport Regulation Of Postsynaptic Membrane Potential Action Potential Sensory Perception Of Pain Membrane Depolarization Protein Heterooligomerization Regulation Of Anion Transport Response To Alkaloid B Cell Activation Adult Behavior	Synaptic Transmission Involved In Micturition Micturition Behavioral Response To Nicotine Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Response To Nicotine Excretion Smooth Muscle Contraction Action Potential Renal System Process Response To Alkaloid Adult Behavior Lateral Geniculate Nucleus Development Muscle Contraction Locomotory Behavior Muscle System Process Regulation Of Membrane Potential Regulation Of Synaptic Transmission Negative Regulation Of Action Potential Single-organism Behavior Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Dopamine Secretion Conditioned Taste Aversion Synaptic Transmission Behavior Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Synaptic Transmission, Dopaminergic Vestibulocochlear Nerve Development Regulation Of Secretion Optic Nerve Morphogenesis Positive Regulation Of Catecholamine Secretion Optic Nerve Development Thalamus Development Response To Organonitrogen Compound Response To Organic Cyclic Compound Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Synaptic Transmission, Dopaminergic Cell-cell Signaling Cation Transmembrane Transport Regulation Of Dopamine Metabolic Process Regulation Of Dopamine Secretion Regulation Of Cellular Localization Cation Transport Ion Transmembrane Transport Positive Regulation Of B Cell Proliferation Central Nervous System Projection Neuron Axonogenesis Social Behavior Response To Cocaine Regulation Of Smooth Muscle Contraction Neural Nucleus Development
Tagcloud ?		300ppm aminobutyric biotin cholinergic dentate deoxynucleotidyl dutp ergic fimbria gabaergic hexachlorophene hilus inputs interneuron interneurons intramyelinic myelin neurogenesis nick nicotinic offspring pnd punctate reelin reversibly septal sgz subgranular vacuolation	a432t a452v ankk1 arrb2 cdh13 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		300ppm aminobutyric biotin cholinergic dentate deoxynucleotidyl dutp ergic fimbria gabaergic hexachlorophene hilus inputs interneuron interneurons intramyelinic myelin neurogenesis nick nicotinic offspring pnd punctate reelin reversibly septal sgz subgranular vacuolation	a432t a452v ankk1 arrb2 cdh13 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?