PIK3IP1 and TMEM218

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIK3IP1	TMEM218
Description		phosphoinositide-3-kinase interacting protein 1	transmembrane protein 218
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane	Cilium Membrane Cell Projection
	Molecular Function	Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity	Protein Binding
	Biological Process	Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways
Drugs
Diseases
GWAS		Fish- and plant-related diet ( 32066663) Metabolite levels ( 23823483) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 32888494)	Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)
Interacting Genes		7 interacting genes: MAGEA11 MFSD11 SLC35A1 TMEM218 UBQLN1 UBQLN2 UPK1B	75 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FFAR2 FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 HSD17B13 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 MUC1 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR
Entrez ID		113791	219854
HPRD ID		17518	19054
Ensembl ID		ENSG00000100100	ENSG00000150433
Uniprot IDs		Q96FE7	A2RU14 E9PI23
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Apical Plasma Membrane Urothelial Plaque Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Negative Regulation Of Clathrin-dependent Endocytosis Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Vacuole Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport N-acetylneuraminate Metabolic Process Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Autophagy Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis	Membrane Plasma Membrane Protein Binding Connexin Complex Regulation Of Myoblast Fusion Gap Junction Channel Activity Gap Junction Bile Acid:sodium Symporter Activity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fucose Binding Gap Junction-mediated Intercellular Transport Renal Water Transport Gap Junction Assembly Fatty Acid Elongation, Saturated Fatty Acid
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