PIK3IP1 and UPK1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIK3IP1	UPK1B
Description		phosphoinositide-3-kinase interacting protein 1	uroplakin 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane	Membrane Apical Plasma Membrane Extracellular Exosome Apical Plasma Membrane Urothelial Plaque
	Molecular Function	Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Response To Bacterium Epithelial Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Fish- and plant-related diet ( 32066663) Metabolite levels ( 23823483) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 32888494)	Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042)
Interacting Genes		7 interacting genes: MAGEA11 MFSD11 SLC35A1 TMEM218 UBQLN1 UBQLN2 UPK1B	59 interacting genes: BCL2L13 BEST2 BIK BNIP2 CATSPERH CD53 CD69 CD79A CERS4 CLDN7 CYB5R3 DAGLA EDAR ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GPR161 GPR37L1 GPX8 ISLR2 ITGB2 KASH5 KCNJ6 KIR2DL3 KLRC1 LMNA MFF MS4A4A NEMP1 PDZK1IP1 PIK3IP1 PLPP4 RHCG SAR1A SDHAF4 SHISA4 SIT1 SLC10A1 SLC10A2 SLC16A2 SLC18A1 SLC35H1 SLC39A2 SPINT1 SSMEM1 STX1A SYT9 TMEM139 TMEM237 TMEM45B TMEM54 TMEM91 TMUB2 UPK3A VSIG1
Entrez ID		113791	7348
HPRD ID		17518	03853
Ensembl ID		ENSG00000100100	ENSG00000114638
Uniprot IDs		Q96FE7	O75841
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Apical Plasma Membrane Urothelial Plaque Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Negative Regulation Of Clathrin-dependent Endocytosis Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Vacuole Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport N-acetylneuraminate Metabolic Process Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Autophagy Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis	Membrane Protein Binding Plasma Membrane Bile Acid:sodium Symporter Activity
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