SFT2D1 and OTULIN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SFT2D1	OTULIN
Description		SFT2 domain containing 1	OTU deubiquitinase with linear linkage specificity
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane	Cytoplasm Cytosol LUBAC Complex
	Molecular Function	Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Protein Transport Vesicle-mediated Transport	Angiogenesis Sprouting Angiogenesis Immune System Process Proteolysis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination
Pathways			Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS			Asthma ( 31619474 31959851 34103634) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058) DHEAS levels ( 34748635)
Interacting Genes		26 interacting genes: AQP6 ARFIP1 CERCAM DERL2 DIABLO MIEF2 MYG1 OTULIN PLEKHB2 PNKP REEP4 RETREG3 SCAND1 SCN3B SDCBP SLC10A1 SLC30A8 SNX1 SPG21 STOM SYT16 TBRG4 TMEM14B TMEM255B TMEM86B TMX2	12 interacting genes: BCL10 CRYAA DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239 UBC
Entrez ID		113402	90268
HPRD ID		12903	14266
Ensembl ID		ENSG00000198818	ENSG00000154124
Uniprot IDs		Q8WV19	Q96BN8
PDB IDs			3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK
Enriched GO Terms of Interacting Partners?			Ubiquitin Protein Ligase Binding Protein K63-linked Deubiquitination
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