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EXOSC8 and EXOSC3
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
BioGRID
(two hybrid)
EXOSC8
EXOSC3
Gene Name
exosome component 8
exosome component 3
Image
Gene Ontology Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Molecular Function
Exoribonuclease Activity
Protein Binding
AU-rich Element Binding
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Biological_process
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Gene Expression
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Isotype Switching
Positive Regulation Of Isotype Switching
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
42 interactors:
AEN
ATF2
COL23A1
COX5A
CRMP1
CWC22
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM90A1
FHOD1
FOXN3
FRG1
LSM1
LSM7
MKRN1
MORN4
MPP6
OTUD4
RASSF1
REL
RPP14
SKIV2L2
SNRPC
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP6
XRN1
XRN2
ZFP36
8 interactors:
APP
ATP5D
CDK5RAP1
EXOSC4
EXOSC5
EXOSC8
EXOSC9
KHSRP
Entrez ID
11340
51010
HPRD ID
09351
16220
Ensembl ID
ENSG00000120699
ENSG00000107371
Uniprot IDs
Q96B26
Q9NQT5
Q9NYS3
PDB IDs
2NN6
2NN6
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
MRNA Metabolic Process
RRNA Metabolic Process
RRNA Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Ribosome Biogenesis
Aromatic Compound Catabolic Process
Nuclear MRNA Surveillance
Ribonucleoprotein Complex Biogenesis
RNA Metabolic Process
Cellular Macromolecule Catabolic Process
NcRNA Metabolic Process
RNA Surveillance
RNA Phosphodiester Bond Hydrolysis
RRNA Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Maturation Of 5.8S RRNA
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Catabolic Process
Nitrogen Compound Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
DNA Deamination
Histone MRNA Catabolic Process
RNA Processing
Cellular Metabolic Process
Histone MRNA Metabolic Process
MRNA Processing
Intracellular MRNA Localization
Metabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
U4 SnRNA 3'-end Processing
TRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
DNA Modification
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RNA Splicing
SnoRNA Metabolic Process
RNA Splicing, Via Transesterification Reactions
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
MRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA Catabolic Process
MRNA Metabolic Process
RRNA Processing
RRNA Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Aromatic Compound Catabolic Process
NcRNA Metabolic Process
Ribosome Biogenesis
Nuclear MRNA Surveillance
Nucleobase-containing Compound Metabolic Process
Ribonucleoprotein Complex Biogenesis
DNA Deamination
RNA Surveillance
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Catabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Phosphodiester Bond Hydrolysis
RNA Metabolic Process
Nitrogen Compound Metabolic Process
Catabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Gene Expression
DNA Modification
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Cell Growth
Regulation Of Growth
Collateral Sprouting In Absence Of Injury
Cellular Metabolic Process
Defense Response To Virus
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Collateral Sprouting
Axon Midline Choice Point Recognition
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Axon Choice Point Recognition
Positive Regulation Of Growth
Neuron Remodeling
Regulation Of MiRNA Metabolic Process
Histone MRNA Catabolic Process
Response To Virus
Immune System Process
RRNA Catabolic Process
Regulation Of Cell Growth
Mitochondrial ATP Synthesis Coupled Proton Transport
Maturation Of 5.8S RRNA
Tagcloud
?
aligned
amenable
avenues
baz2a
bioinformatic
candidates
cdk13
chem
dapk1
digest
dilution
dst
hdms
hierarchical
inhbe
kat2b
kif20b
linkages
noninvasive
pancreatic
proteomics
resectable
silva
smc1b
spag5
synapt
tryptic
unsupervised
urgent
Tagcloud (Difference)
?
aligned
amenable
avenues
baz2a
bioinformatic
candidates
cdk13
chem
dapk1
digest
dilution
dst
hdms
hierarchical
inhbe
kat2b
kif20b
linkages
noninvasive
pancreatic
proteomics
resectable
silva
smc1b
spag5
synapt
tryptic
unsupervised
urgent
Tagcloud (Intersection)
?