GABRG3

Description		gamma-aminobutyric acid type A receptor subunit gamma3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Plasma Membrane Microtubule Cytoskeleton Membrane Dendrite Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Synaptic Membrane Postsynapse GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Response To Xenobiotic Stimulus Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Eszopiclone Alprazolam Alprazolam Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Ethanol Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Estazolam Sevoflurane Glutethimide Camazepam Camazepam Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Anthropometric traits (multi-trait analysis) ( 30166351) Asthma and eczema ( 34155719) Bitter beverage consumption ( 31046077) Corneal curvature ( 22969067) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Gene methylation in lung tissue ( 25713168) General risk tolerance (MTAG) ( 30643258) High-grade serous ovarian cancer ( 31469419) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Type 2 diabetes ( 30130595) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Weight ( 28552196)
Interacting Genes		1 interacting genes: GABARAP
Entrez ID		2567
HPRD ID		02579
Ensembl ID		ENSG00000182256
Uniprot IDs		Q99928
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein K48-linked Ubiquitination Phosphatidylethanolamine Binding GABA Receptor Binding Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Smooth Endoplasmic Reticulum Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Cellular Response To Nitrogen Starvation Regulation Of Protein Polyubiquitination Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Rac Protein Signal Transduction Microtubule Associated Complex Beta-tubulin Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Autophagosome Maturation Sperm Midpiece Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Extrinsic Apoptotic Signaling Pathway Phospholipid Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagosome Organization Autophagosome Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process GABA-ergic Synapse Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Axoneme Positive Regulation Of Proteasomal Protein Catabolic Process Protein-containing Complex Disassembly Regulation Of Protein Localization To Cell Periphery Macroautophagy Vacuole Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization To Membrane Cellular Response To Starvation Positive Regulation Of Proteolysis Regulation Of Protein Ubiquitination Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Starvation Regulation Of Post-translational Protein Modification Microtubule Binding Cellular Response To Nutrient Levels
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