EXOC2 and ESX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EXOC2	ESX1
Description		exocyst complex component 2	ESX homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytosol Plasma Membrane Membrane Flemming Body	Chromatin Nucleus Cytoplasm Nuclear Speck
	Molecular Function	Protein Binding Protein Kinase Binding Small GTPase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Membrane Fission Vesicle Tethering Involved In Exocytosis Regulation Of Entry Of Bacterium Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Neuron Development Regulation Of Cell Cycle
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 21700618 27539887 33549134) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs. brown/black hair color ( 30531825) Blood metabolite levels ( 31502714) Brown vs. black hair color ( 30531825) Dental caries ( 23064961) Diffuse large B cell lymphoma ( 25261932) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 33627673 29891935) Haemorrhoidal disease ( 33888516) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998 29785010 31959993 30054594) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 28196072) Medication use (antiglaucoma preparations and miotics) ( 31015401) Melanoma ( 28212542) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Non-melanoma skin cancer ( 23548203) Optic cup area ( 31798171) Primary central nervous system lymphoma ( 31102405) Psoriasis ( 23143594 25574825 25903422) Schizophrenia ( 22885689) Sum eosinophil basophil counts ( 27863252) Tanning ( 19340012) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waldenström macroglobulinemia / lymphoplasmacytic lymphoma ( 30305637)
Interacting Genes		9 interacting genes: CDKN2A ESX1 EXOC3 EXOC7 EXOC8 RALA RANBP9 SERGEF VPS53	2 interacting genes: EXOC2 TRAP1
Entrez ID		55770	80712
HPRD ID		11544	06503
Ensembl ID		ENSG00000112685	ENSG00000123576
Uniprot IDs		Q96KP1	Q8N693
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Tethering Involved In Exocytosis Exocyst Vesicle Tethering Vesicle Docking Involved In Exocytosis Membrane Fission Exocytosis Vesicle Docking Mitotic Cytokinesis Organelle Localization By Membrane Tethering Cytoskeleton-dependent Cytokinesis Membrane Docking Secretion By Cell Secretion Flemming Body Vesicle-mediated Transport Establishment Of Protein Localization Ligase Inhibitor Activity Ras Protein Signal Transduction Intracellular Protein Localization Edg-2 Lysophosphatidic Acid Receptor Binding Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution Exocyst Localization Organelle Localization Protein Transport Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Senescence-associated Heterochromatin Focus Localization Within Membrane Vesicle-mediated Transport To The Plasma Membrane Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Immature T Cell Proliferation In Thymus Growth Cone GARP Complex EARP Complex Negative Regulation Of Immature T Cell Proliferation Mitochondrial Depolarization Oncogene-induced Cell Senescence Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Entry Of Bacterium Into Host Cell Positive Regulation Of Mitotic Cytokinetic Process Membrane Organization Positive Regulation Of Apoptotic Process Involved In Development Membrane Raft Localization Midbody Growth Cone Membrane Vesicle-mediated Cholesterol Transport Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Myeloid Cell Apoptotic Process	Translational Attenuation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Cellular Respiration Protein Kinase Binding Regulation Of Entry Of Bacterium Into Host Cell Vesicle Tethering Involved In Exocytosis Intracellular Organelle Lumen Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Exocyst Tumor Necrosis Factor Receptor Binding ATP-dependent Protein Folding Chaperone Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Flemming Body Vesicle Docking Involved In Exocytosis Vesicle Tethering Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Membrane Fission Vesicle Docking Golgi To Plasma Membrane Transport Mitotic Cytokinesis Mitochondrial Intermembrane Space Organelle Localization By Membrane Tethering Cytoskeleton-dependent Cytokinesis Membrane Docking Post-Golgi Vesicle-mediated Transport Unfolded Protein Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Vesicle-mediated Transport To The Plasma Membrane
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