EXOC2 and VPS53

Number of citations of the paper that reports this interaction (PubMedID 20685960)
40

Data Source:
BioGRID (two hybrid)

		EXOC2	VPS53
Description		exocyst complex component 2	VPS53 subunit of GARP complex
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytosol Plasma Membrane Membrane Flemming Body	GARP Complex Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Recycling Endosome EARP Complex
	Molecular Function	Protein Binding Protein Kinase Binding Small GTPase Binding	Protein Binding
	Biological Process	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Membrane Fission Vesicle Tethering Involved In Exocytosis Regulation Of Entry Of Bacterium Into Host Cell	Protein Targeting To Lysosome Lysosomal Transport Protein Transport Vesicle-mediated Transport Cytosolic Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Vesicle-mediated Cholesterol Transport
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 21700618 27539887 33549134) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs. brown/black hair color ( 30531825) Blood metabolite levels ( 31502714) Brown vs. black hair color ( 30531825) Dental caries ( 23064961) Diffuse large B cell lymphoma ( 25261932) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 33627673 29891935) Haemorrhoidal disease ( 33888516) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998 29785010 31959993 30054594) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 28196072) Medication use (antiglaucoma preparations and miotics) ( 31015401) Melanoma ( 28212542) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Non-melanoma skin cancer ( 23548203) Optic cup area ( 31798171) Primary central nervous system lymphoma ( 31102405) Psoriasis ( 23143594 25574825 25903422) Schizophrenia ( 22885689) Sum eosinophil basophil counts ( 27863252) Tanning ( 19340012) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waldenström macroglobulinemia / lymphoplasmacytic lymphoma ( 30305637)	Apolipoprotein A1 levels ( 32203549) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Prostate cancer ( 23535732) Triglyceride levels ( 32203549) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		9 interacting genes: CDKN2A ESX1 EXOC3 EXOC7 EXOC8 RALA RANBP9 SERGEF VPS53	2 interacting genes: EXOC2 VPS52
Entrez ID		55770	55275
HPRD ID		11544	07720
Ensembl ID		ENSG00000112685	ENSG00000141252
Uniprot IDs		Q96KP1	B3KS06 Q5VIR6
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Tethering Involved In Exocytosis Exocyst Vesicle Tethering Vesicle Docking Involved In Exocytosis Membrane Fission Exocytosis Vesicle Docking Mitotic Cytokinesis Organelle Localization By Membrane Tethering Cytoskeleton-dependent Cytokinesis Membrane Docking Secretion By Cell Secretion Flemming Body Vesicle-mediated Transport Establishment Of Protein Localization Ligase Inhibitor Activity Ras Protein Signal Transduction Intracellular Protein Localization Edg-2 Lysophosphatidic Acid Receptor Binding Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution Exocyst Localization Organelle Localization Protein Transport Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Senescence-associated Heterochromatin Focus Localization Within Membrane Vesicle-mediated Transport To The Plasma Membrane Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Immature T Cell Proliferation In Thymus Growth Cone GARP Complex EARP Complex Negative Regulation Of Immature T Cell Proliferation Mitochondrial Depolarization Oncogene-induced Cell Senescence Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Entry Of Bacterium Into Host Cell Positive Regulation Of Mitotic Cytokinetic Process Membrane Organization Positive Regulation Of Apoptotic Process Involved In Development Membrane Raft Localization Midbody Growth Cone Membrane Vesicle-mediated Cholesterol Transport Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Myeloid Cell Apoptotic Process	Vesicle-mediated Transport To The Plasma Membrane Post-Golgi Vesicle-mediated Transport Embryonic Ectodermal Digestive Tract Development Golgi Vesicle Transport GARP Complex EARP Complex Ectodermal Cell Differentiation Localization Within Membrane Vesicle-mediated Cholesterol Transport Regulation Of Entry Of Bacterium Into Host Cell Vesicle Tethering Involved In Exocytosis Exocyst Golgi To Vacuole Transport Embryonic Digestive Tract Development Intracellular Cholesterol Transport Intracellular Sterol Transport Intracellular Lipid Transport Vesicle-mediated Transport Protein Transport Flemming Body Vesicle Docking Involved In Exocytosis Vesicle Tethering Membrane Fission Establishment Of Protein Localization Syntaxin Binding Cellular Localization Digestive Tract Development Cholesterol Transport Mitotic Cytokinesis Vesicle Docking Golgi To Plasma Membrane Transport Endocytic Recycling Sterol Transport Organelle Localization By Membrane Tethering Intracellular Protein Localization Cytoskeleton-dependent Cytokinesis Membrane Docking Retrograde Transport, Endosome To Golgi Trans-Golgi Network Membrane Lysosomal Transport Cytosolic Transport Recycling Endosome Organic Hydroxy Compound Transport Embryonic Organ Development Vacuolar Transport Protein Targeting Exocytosis Tube Development Postsynapse Presynapse
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