NR2F2 and BCL11A

Number of citations of the paper that reports this interaction (PMID 10744719)
57

Data Source:
HPRD (in vitro, two hybrid)

		NR2F2	BCL11A
Gene Name		nuclear receptor subfamily 2, group F, member 2	B-cell CLL/lymphoma 11A (zinc finger protein)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Retinoic Acid Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Lipid Metabolic Process Signal Transduction Skeletal Muscle Tissue Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Blood Vessel Morphogenesis Limb Development Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Protein Sumoylation B Cell Differentiation T Cell Differentiation Negative Regulation Of Axon Extension Negative Regulation Of Protein Homooligomerization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Collateral Sprouting Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Development Negative Regulation Of Dendrite Development
Pathways		Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Sex hormone-binding globulin levels ( 22829776)	Attention deficit hyperactivity disorder ( 22012869) Beta thalassemia/hemoglobin E disease ( 20183929) F-cell distribution ( 21326311 17767159) Fetal hemoglobin levels ( 18245381 20018918) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Mean corpuscular volume ( 19862010) Monocyte early outgrowth colony forming units ( 21493818) Red blood cell traits ( 23222517) Sickle cell anemia (haemolysis) ( 23406172) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		19 interactors: BCL11A BCL11B BIK EP300 FAM46A HDAC1 HIPK3 LCK MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 SETD7 SQSTM1 TRIM24 TRIP4	20 interactors: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 GMCL1P1 LMO1 NCK2 NR2E1 NR2E3 NR2F1 NR2F2 NR2F6 SIRT1 SUMO1 SUMO2 SUMO3 YME1L1 ZBTB24
Entrez ID		7026	53335
HPRD ID		00139	05949
Ensembl ID		ENSG00000185551	ENSG00000119866
Uniprot IDs		F1D8R0 P24468	D6W5D9 D9YZV9 Q9H165
PDB IDs		3CJW
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Peptidyl-amino Acid Modification Negative Regulation Of Biosynthetic Process Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Chromatin Organization Negative Regulation Of Cellular Metabolic Process Response To Steroid Hormone Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Response To Hormone Chromatin Modification Response To Organic Substance Cellular Protein Modification Process Regulation Of Apoptotic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Histone Modification Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Death	Positive Regulation Of Cellular Metabolic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Cellular Senescence Positive Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Aging Negative Regulation Of Cellular Metabolic Process Cell Differentiation Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Senescence Protein Sumoylation Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Steroid Hormone Multicellular Organismal Development Generation Of Neurons Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Neurogenesis System Development Positive Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Organ Development Response To Hormone Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Forebrain Development Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca overlooked prenatal pws rearrangements spanning tier tp63	beadchip cpgs cues enhancers erythroblasts erythroid erythropoiesis fetal globin happen hbf hemoglobin highlighting humanmethylation illumina maps mendelian methylated methylation methylome moves overlap red repress sickle switch tend thalassemia unanticipated
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca overlooked prenatal pws rearrangements spanning tier tp63	beadchip cpgs cues enhancers erythroblasts erythroid erythropoiesis fetal globin happen hbf hemoglobin highlighting humanmethylation illumina maps mendelian methylated methylation methylome moves overlap red repress sickle switch tend thalassemia unanticipated
Tagcloud (Intersection) ?