NR2F2 and NCOR2

Number of citations of the paper that reports this interaction (PubMedID 16219912)
0

Data Source:
HPRD (in vitro)

		NR2F2	NCOR2
Description		nuclear receptor subfamily 2 group F member 2	nuclear receptor corepressor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcription Repressor Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Retinoic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Enzyme Activator Activity Nuclear Receptor Binding Nuclear Glucocorticoid Receptor Binding Histone Deacetylase Binding Nuclear Retinoic Acid Receptor Binding Protein-containing Complex Binding Nuclear Retinoid X Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Skeletal Muscle Tissue Development Female Gonad Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Cell Differentiation Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Lymphatic Endothelial Cell Fate Commitment Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Interneuron Migration	Negative Regulation Of Transcription By RNA Polymerase II Lactation Regulation Of Ketone Metabolic Process Cerebellum Development Response To Estradiol Estrous Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription
Pathways		Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Birth weight ( 31043758) Cannabis use ( 27023175) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphangioleiomyomatosis (sporadic) ( 31000673) Metabolite levels ( 23823483) Motion sickness ( 25628336) Optic disc area ( 25631615) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 33547301) Sex hormone-binding globulin levels ( 22829776) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Appendicular lean mass ( 33097823) Clubfoot ( 24667120) Cocaine dependence ( 23958962) Cognitive performance ( 19734545) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 30061609) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		21 interacting genes: BCL11A BCL11B BIK EP300 FOXP1 FOXP2 FOXP4 HDAC1 HIPK3 MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 SETD7 SQSTM1 TENT5A TRIM24 TRIP4	92 interacting genes: ADRB2 AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CAMK2B CBFA2T2 CDK2 CEBPB CEP63 CHUK CIRSR CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 KPNA4 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBC UBE2I VDR YWHAE ZBTB16 ZBTB5 ZBTB7A
Entrez ID		7026	9612
HPRD ID		00139	02910
Ensembl ID		ENSG00000185551	ENSG00000196498
Uniprot IDs		F1D8R0 P24468	C9J0Q5 C9JE98 Q9Y618
PDB IDs		3CJW	1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX 6PDZ 7SQA 8AQM 8AQN 8B8W 8B8X 8B8Y 8B8Z 8B90 8B91 8B92 8B93 8B94 8B95 8X7E
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Nuclear Receptor Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Chromatin Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Zinc Ion Binding Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Androgen Receptor Binding Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Chromatin Organization Macromolecule Biosynthetic Process Negative Regulation Of Protein Oligomerization Regulation Of Programmed Cell Death	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus DNA Binding Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex DNA-templated Transcription Hormone-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Signal Transduction Cell Differentiation Transcription Cis-regulatory Region Binding Regulation Of Multicellular Organismal Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Transcription By RNA Polymerase II
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