NR2F2 and TRIP4

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		NR2F2	TRIP4
Gene Name		nuclear receptor subfamily 2, group F, member 2	thyroid hormone receptor interactor 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center
	Molecular Function	Retinoic Acid Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding	Protease Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding Histone Acetyltransferase Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Lipid Metabolic Process Signal Transduction Skeletal Muscle Tissue Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Blood Vessel Morphogenesis Limb Development Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment	Transcription From RNA Polymerase II Promoter Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Toxin Transport
Pathways		Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		19 interactors: BCL11A BCL11B BIK EP300 FAM46A HDAC1 HIPK3 LCK MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 SETD7 SQSTM1 TRIM24 TRIP4	22 interactors: AR ASCC2 ASCC3 CREBBP EP300 ESR1 ESR2 GTF2A1 JUN NCOA1 NEK6 NFKB1 NR2F2 PAX9 PPARG RARA RELA RXRA SHD TBP THRB XBP1
Entrez ID		7026	9325
HPRD ID		00139	05140
Ensembl ID		ENSG00000185551	ENSG00000103671
Uniprot IDs		F1D8R0 P24468	Q15650
PDB IDs		3CJW	2E5O
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Peptidyl-amino Acid Modification Negative Regulation Of Biosynthetic Process Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Chromatin Organization Negative Regulation Of Cellular Metabolic Process Response To Steroid Hormone Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Response To Hormone Chromatin Modification Response To Organic Substance Cellular Protein Modification Process Regulation Of Apoptotic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Histone Modification Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Death	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Response To Lipid Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Steroid Hormone Mediated Signaling Pathway Cellular Response To Hormone Stimulus Cellular Response To Lipid Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Steroid Hormone Regulation Of RNA Metabolic Process Response To Hormone Hormone-mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Cellular Response To Steroid Hormone Stimulus Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Gland Development
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca overlooked prenatal pws rearrangements spanning tier tp63	abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 unsuspected zcwpw1
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca overlooked prenatal pws rearrangements spanning tier tp63	abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 unsuspected zcwpw1
Tagcloud (Intersection) ?