RPRM and LPAR6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPRM	LPAR6
Description		reprimo, TP53 dependent G2 arrest mediator homolog	lysophosphatidic acid receptor 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Protein Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle	Blastocyst Hatching Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways			G alpha (q) signalling events P2Y receptors
Drugs			Promethazine
Diseases			Localized autosomal recessive hypotrichosis Woolly hair, including: Autosomal-dominant woolly hair (ADWH); Autosomal-recessive woolly hair (ARWH); Autosomal-recessive woolly hair with or without hypotrichosis
GWAS		Anti-saccade response ( 29064472) Blood trace element (Zn levels) ( 23720494) Heel bone mineral density ( 30598549) Lung cancer ( 28604730) Recurrent major depressive disorder x sex interaction ( 34099189)	Lymphocyte count ( 32888494)
Interacting Genes		80 interacting genes: ADGRG3 AMIGO1 AQP6 ARFIP1 ASGR2 BNIP3 BSCL2 BTNL9 C16orf54 CD33 CD53 CD69 CLDN5 CLDN7 CLDN9 CLEC17A CLEC2D COQ8A CREB3 CXorf66 EHHADH EMP1 FAM209A FAM210B FATE1 FBXL19 FCGR1A FFAR2 FGD2 FKBP7 FNDC9 GAD2 GJA5 GJB3 GJB5 GNG13 GPR37L1 GPR42 GPX8 HHLA2 HIP1 HSD17B13 KCNJ6 LAPTM5 LHFPL5 LMNA LPAR6 MPP1 MS4A4A MTIF3 OPRD1 OPRM1 PBX3 PDZK1IP1 PLEKHF2 PNKP SCAND1 SDCBP SENP2 SLC18A1 SLC38A1 SMIM3 SNX11 SNX12 SNX3 SPACA1 SPCS1 STOM SUSD3 SYT16 TM4SF18 TMEM106C TMEM237 TMEM79 TMEM80 TMEM86B TSPO2 TTPA WDFY2 ZDHHC22	4 interacting genes: EMP1 RPRM SEC22A SMIM3
Entrez ID		56475	10161
HPRD ID		18002	16465
Ensembl ID		ENSG00000177519	ENSG00000139679
Uniprot IDs		Q9NS64	B3KVQ5 P43657
PDB IDs			9ITB 9ITE
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Negative Regulation Of Early Endosome To Late Endosome Transport Connexin Complex Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Gap Junction Channel Activity Endoplasmic Reticulum Phosphatidylinositol Binding External Side Of Plasma Membrane Gap Junction Gamma-aminobutyric Acid Biosynthetic Process Phosphatidylinositol Phosphate Binding Late Endosome To Golgi Transport
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