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DDX19B and SKP1
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
HPRD
(two hybrid)
DDX19B
SKP1
Gene Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
S-phase kinase-associated protein 1
Image
Gene Ontology Annotations
Cellular Component
Nuclear Envelope
Nuclear Pore
Cytoplasm
Membrane
Nuclear Membrane
Extracellular Vesicular Exosome
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Extracellular Vesicular Exosome
Molecular Function
RNA Binding
Helicase Activity
ATP Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Biological Process
MRNA Export From Nucleus
Protein Transport
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Notch Signaling Pathway
Circadian Rhythm
Viral Process
Protein Ubiquitination
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by NOTCH1 HD Domain Mutants in Cancer
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Cyclin E associated events during G1/S transition
Signaling by Wnt
Regulation of PLK1 Activity at G2/M Transition
Downstream signaling events of B Cell Receptor (BCR)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Degradation of beta-catenin by the destruction complex
G1/S Transition
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
Signaling by NOTCH1 in Cancer
Prolactin receptor signaling
Mitotic G1-G1/S phases
truncations of AMER1 destabilize the destruction complex
Signaling by NOTCH
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Regulation of APC/C activators between G1/S and early anaphase
S Phase
Signaling by ERBB4
APC/C-mediated degradation of cell cycle proteins
Signaling by Interleukins
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Interleukin-1 signaling
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic G2-G2/M phases
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
HIV Infection
APC truncation mutants have impaired AXIN binding
G2/M Transition
APC truncation mutants are not K63 polyubiquitinated
S37 mutants of beta-catenin aren't phosphorylated
Signaling by NOTCH1
Class I MHC mediated antigen processing & presentation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FBXW7 Mutants and NOTCH1 in Cancer
Vpu mediated degradation of CD4
G1 Phase
Cytokine Signaling in Immune system
Cell Cycle, Mitotic
NOTCH1 Intracellular Domain Regulates Transcription
Cyclin D associated events in G1
Nuclear signaling by ERBB4
Activation of NF-kappaB in B cells
SCF-beta-TrCP mediated degradation of Emi1
Regulation of mitotic cell cycle
Signaling by Hedgehog
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Degradation of GLI1 by the proteasome
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Protein-Protein Interactions
13 interactors:
APP
B3GALT4
DCK
GNB2L1
IKBKG
MIF4GD
NUP214
POT1
PRPSAP1
RWDD2B
SKP1
TERF1
XPO7
67 interactors:
ANKRD36BP1
APIP
BTRC
CACYBP
CCNA2
CDCA3
CDK2
CDK4
CDK9
CDKN1B
CENPE
CKS1B
CTNNB1
CUL1
CUL7
DDX19B
FBXL2
FBXL3
FBXL4
FBXL5
FBXL6
FBXL8
FBXO11
FBXO15
FBXO16
FBXO17
FBXO18
FBXO2
FBXO25
FBXO28
FBXO3
FBXO32
FBXO34
FBXO4
FBXO44
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GLMN
GPS1
HSP90AA1
KCTD9
LMO2
MED21
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPP1CA
RBX1
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UBE2D3
UHRF2
Entrez ID
11269
6500
HPRD ID
05781
03255
Ensembl ID
ENSG00000157349
Uniprot IDs
B4DL69
Q9UMR2
P63208
PDB IDs
3EWS
3FHC
3FHT
3FMO
3FMP
3G0H
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
4I6J
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Telomere Maintenance Via Telomerase
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Negative Regulation Of Telomerase Activity
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Transferase Activity
Regulation Of Telomerase Activity
Negative Regulation Of Catalytic Activity
Regulation Of Telomere Maintenance
RNA-dependent DNA Replication
Negative Regulation Of DNA Biosynthetic Process
Regulation Of Catalytic Activity
Telomere Maintenance Via Telomere Lengthening
Viral Process
Protein Export From Nucleus
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of DNA Biosynthetic Process
Negative Regulation Of DNA Replication
Regulation Of Cellular Protein Metabolic Process
Regulation Of Proteolysis
Regulation Of Translation
Positive Regulation Of Proteolysis
Regulation Of Protein Tyrosine Kinase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of DNA Strand Elongation
Telomere Maintenance
Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Negative Regulation Of Chromosome Organization
Regulation Of Protein Catabolic Process
Synaptic Growth At Neuromuscular Junction
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Positive Regulation Of CAMP Catabolic Process
Regulation Of Cell Cycle
Negative Regulation Of DNA Metabolic Process
Negative Regulation Of Hydrogen Peroxide-induced Neuron Death
Telomere Formation Via Telomerase
Collateral Sprouting In Absence Of Injury
Telomeric Loop Formation
Age-dependent Telomere Shortening
Posttranscriptional Regulation Of Gene Expression
Positive Regulation Of Mitotic Cell Cycle
Nuclear Export
MRNA Transport
G2/M Transition Of Mitotic Cell Cycle
Telomere Maintenance Via Telomere Shortening
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Regulation Of DNA Replication
Positive Regulation Of Cellular Protein Metabolic Process
RNA Transport
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteolysis
Cell Cycle
Cell Cycle Process
Cellular Protein Modification Process
Catabolic Process
Cellular Protein Metabolic Process
Regulation Of Cell Cycle
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Protein Metabolic Process
Negative Regulation Of Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Cycle Process
Mitotic Cell Cycle Phase Transition
Regulation Of Protein Metabolic Process
Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Ubiquitination
Cellular Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Protein Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Metabolic Process
Regulation Of Protein Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Cell Division
Regulation Of Ubiquitin-protein Transferase Activity
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Mitotic Nuclear Division
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud
?
ankyrin
attenuates
bc
belonging
binds
box
collection
degenerate
elongation
elongin
hippel
inhibiting
initially
interacting
jak
lindau
motif
multifunctional
multiprotein
participates
pol
repeat
socs
spry
stat
suppressor
vhl
von
wd
Tagcloud (Difference)
?
ankyrin
attenuates
bc
belonging
binds
box
collection
degenerate
elongation
elongin
hippel
inhibiting
initially
interacting
jak
lindau
motif
multifunctional
multiprotein
participates
pol
repeat
socs
spry
stat
suppressor
vhl
von
wd
Tagcloud (Intersection)
?