HPS5 and HPS6

Number of citations of the paper that reports this interaction (PMID 12548288)
24

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		HPS5	HPS6
Gene Name		Hermansky-Pudlak syndrome 5	Hermansky-Pudlak syndrome 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	BLOC-2 Complex	Endoplasmic Reticulum Membrane BLOC-2 Complex Early Endosome Membrane
	Molecular Function		Rab GTPase Binding GTP-dependent Protein Binding
	Biological Process	Organelle Organization Blood Coagulation Pigmentation	Organelle Organization Blood Coagulation Melanocyte Differentiation Protein Localization To Membrane
Pathways
Drugs
Diseases
GWAS		Amyloid A Levels ( 21124955) Metabolic traits ( 21886157)
Protein-Protein Interactions		2 interactors: HPS6 ITGA3	9 interactors: CREB1 EP300 HPS5 KIAA0020 MARK4 MNAT1 OSGEP PIK3CB TTC19
Entrez ID		11234	79803
HPRD ID		07395	08471
Ensembl ID		ENSG00000110756	ENSG00000166189
Uniprot IDs		Q9UPZ3	Q86YV9
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Dendritic Spine Maintenance Response To Wounding Renal Filtration Dendritic Spine Organization Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Cellular Component Maintenance Exploration Behavior Mesodermal Cell Differentiation Melanocyte Differentiation Regulation Of Establishment Of Protein Localization To Plasma Membrane Response To Gonadotropin Neuroepithelial Cell Differentiation Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Tissue Development Developmental Pigmentation Maternal Process Involved In Female Pregnancy Positive Regulation Of Epithelial Cell Migration Regulation Of BMP Signaling Pathway Mesoderm Formation Mesoderm Morphogenesis Renal System Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pigmentation Positive Regulation Of Cell-substrate Adhesion Memory Integrin-mediated Signaling Pathway Formation Of Primary Germ Layer Negative Regulation Of Cell Projection Organization Nephron Development Mesoderm Development Regulation Of Epithelial Cell Migration	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Viral Process Cell Cycle Process Histone H2B Acetylation Protein Stabilization Posttranscriptional Regulation Of Gene Expression Threonylcarbamoyladenosine Biosynthetic Process Viral Process Cell Cycle Regulation Of Body Fluid Levels Phosphatidylinositol-mediated Signaling N-terminal Peptidyl-lysine Acetylation Regulation Of Protein Stability Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Viral Process G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle Process Circadian Rhythm Threonylcarbamoyladenosine Metabolic Process Regulation Of Tubulin Deacetylation Cellular Response To Fibroblast Growth Factor Stimulus Mitotic Cell Cycle Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Organelle Organization Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Lung Development Positive Regulation By Host Of Viral Transcription Embryonic Cleavage Mitochondrial Respiratory Chain Complex III Assembly Respiratory Tube Development Regulation Of Cellular Protein Metabolic Process Response To Hormone Fc Receptor Signaling Pathway N-terminal Protein Amino Acid Acetylation Response To Stress Regulation Of Clathrin-mediated Endocytosis Lung Saccule Development
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