HPS5 and ITGA3

Number of citations of the paper that reports this interaction (PMID 10094488)
9

Data Source:
HPRD (two hybrid)

		HPS5	ITGA3
Gene Name		Hermansky-Pudlak syndrome 5	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	BLOC-2 Complex	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Growth Cone Filopodium Membrane Integrin Alpha3-beta1 Complex Receptor Complex Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Vesicular Exosome Invadopodium Membrane Cell Periphery Synaptic Membrane
	Molecular Function		Glycoprotein Binding Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Organelle Organization Blood Coagulation Pigmentation	Neuron Migration Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation Memory Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Response To Drug Skin Development Mesodermal Cell Differentiation Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Dendritic Spine Maintenance Renal Filtration
Pathways			Laminin interactions Integrin cell surface interactions Basigin interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Amyloid A Levels ( 21124955) Metabolic traits ( 21886157)
Protein-Protein Interactions		2 interactors: HPS6 ITGA3	15 interactors: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 RABIF TIMP2 TSPAN4
Entrez ID		11234	3675
HPRD ID		07395	05431
Ensembl ID		ENSG00000110756	ENSG00000005884
Uniprot IDs		Q9UPZ3	P26006
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Dendritic Spine Maintenance Response To Wounding Renal Filtration Dendritic Spine Organization Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Cellular Component Maintenance Exploration Behavior Mesodermal Cell Differentiation Melanocyte Differentiation Regulation Of Establishment Of Protein Localization To Plasma Membrane Response To Gonadotropin Neuroepithelial Cell Differentiation Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Tissue Development Developmental Pigmentation Maternal Process Involved In Female Pregnancy Positive Regulation Of Epithelial Cell Migration Regulation Of BMP Signaling Pathway Mesoderm Formation Mesoderm Morphogenesis Renal System Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pigmentation Positive Regulation Of Cell-substrate Adhesion Memory Integrin-mediated Signaling Pathway Formation Of Primary Germ Layer Negative Regulation Of Cell Projection Organization Nephron Development Mesoderm Development Regulation Of Epithelial Cell Migration	Cell Activation Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Calcium-independent Cell-matrix Adhesion Cellular Component Assembly Cell Junction Assembly Leukocyte Activation Positive Regulation Of Cell Development Cell-cell Adhesion Mediated By Integrin Regulation Of Neuron Differentiation Positive Regulation Of Catalytic Activity System Development Regulation Of Cell Adhesion Extracellular Matrix Disassembly Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Metabolic Process Cell Adhesion Mediated By Integrin Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Cell Adhesion Regulation Of Neurogenesis Multicellular Organismal Development Cardiocyte Differentiation Anatomical Structure Development Lymphocyte Activation Positive Regulation Of Neurogenesis Blood Coagulation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Hemostasis Immune System Process B Cell Activation Cell-matrix Adhesion Response To Hormone Regulation Of Endocytosis Cardiac Muscle Tissue Development Muscle Structure Development Developmental Process Regulation Of Catalytic Activity Single Organismal Cell-cell Adhesion Neurogenesis Cell-substrate Adhesion Positive Regulation Of Hydrolase Activity Protein Maturation Striated Muscle Cell Differentiation Regulation Of Body Fluid Levels Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process
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