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SEC63 and SEC61B
Number of citations of the paper that reports this interaction (PubMedID
10799540
)
0
Data Source:
HPRD
(in vitro)
SEC63
SEC61B
Description
SEC63 protein translocation regulator
SEC61 translocon subunit beta
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Sec62/Sec63 Complex
Endoplasmic Reticulum
Sec61 Translocon Complex
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Endoplasmic Reticulum Sec Complex
Endoplasmic Reticulum Quality Control Compartment
Molecular Function
RNA Binding
Protein Binding
Protein Transmembrane Transporter Activity
Signaling Receptor Activity
RNA Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Ribosome Binding
Epidermal Growth Factor Binding
Biological Process
Liver Development
Protein Targeting To Membrane
SRP-dependent Cotranslational Protein Targeting To Membrane
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Protein Transport
Post-translational Protein Targeting To Membrane, Translocation
Nitrogen Cycle Metabolic Process
SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation
Intracellular Protein Transport
Protein Transport
Retrograde Protein Transport, ER To Cytosol
Post-translational Protein Targeting To Membrane, Translocation
ERAD Pathway
Pathways
ER-Phagosome pathway
SRP-dependent cotranslational protein targeting to membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
Polycystic liver disease
GWAS
Graft survival time in renal transplantation (donor effect) x APOL1 genotype interaction (
32080893
)
Adult body size (
32376654
)
Asthma (
31959851
)
Callous-unemotional behaviour (
23874384
)
Gestational age at birth (maternal effect) (
28877031
)
HDL cholesterol levels (
32203549
)
Smoking status (ever vs never smokers) (
30643258
)
Triglyceride levels (
32203549
)
Interacting Genes
5 interacting genes:
HSPA5
MEOX2
RNF10
SEC61B
SEC62
19 interacting genes:
APOB
ARL6
ATP13A2
AURKA
BAG6
BMPR1A
BUB1
CALM1
CDKN2A
FBXW7
GET3
GET4
MCC
MLH3
MUTYH
SEC63
SERP1
SPC25
TRAM1
Entrez ID
11231
10952
HPRD ID
09783
06715
Ensembl ID
ENSG00000025796
ENSG00000106803
Uniprot IDs
A0A0S2Z5M1
Q9UGP8
P60468
PDB IDs
6W6L
8B6L
8DNV
8DNW
8DNX
8DNY
8DNZ
8DO0
8DO1
8DO2
8DO3
8OJ0
8OJ8
Enriched GO Terms of Interacting Partners
?
Post-translational Protein Targeting To Membrane, Translocation
Intracellular Protein Transmembrane Transport
Protein Transmembrane Transport
ERAD Pathway
Proteasomal Protein Catabolic Process
Ribosome Binding
Regulation Of Protein Folding In Endoplasmic Reticulum
Intracellular Protein Transport
Endoplasmic Reticulum Sec Complex
Protein Catabolic Process
Cerebellum Structural Organization
Proteolysis Involved In Protein Catabolic Process
Regulation Of ATF6-mediated Unfolded Protein Response
Epidermal Growth Factor Binding
Regulation Of Protein Folding
Maintenance Of Protein Localization In Endoplasmic Reticulum
Macromolecule Catabolic Process
PERK-mediated Unfolded Protein Response
Response To Endoplasmic Reticulum Stress
ER Overload Response
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum Chaperone Complex
Negative Regulation Of PERK-mediated Unfolded Protein Response
Protein Transport
IRE1-mediated Unfolded Protein Response
Transmembrane Transport
Cerebellar Purkinje Cell Layer Development
Protein Folding In Endoplasmic Reticulum
Positive Regulation Of Transcription By RNA Polymerase II
Intracellular Transport
Proteolysis
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Somite Specification
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Postsynapse To Nucleus Signaling Pathway
Negative Regulation Of Schwann Cell Proliferation
Extrinsic Component Of Postsynaptic Density Membrane
Sec61 Translocon Complex
SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation
Establishment Of Protein Localization
Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Misfolded Protein Binding
Segment Specification
Somite Development
Cotranslational Protein Targeting To Membrane
Negative Regulation Of Glial Cell Proliferation
Retrograde Protein Transport, ER To Cytosol
Anatomical Structure Arrangement
Protein Targeting To Membrane
Protein Insertion Into ER Membrane
Establishment Of Protein Localization To Membrane
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Tail-anchored Membrane Protein Insertion Into ER Membrane
Protein Insertion Into Membrane
Regulation Of Protein Stability
Protein Targeting
BAT3 Complex
Protein Targeting To ER
Establishment Of Protein Localization
Maintenance Of Unfolded Protein
Establishment Of Protein Localization To Endoplasmic Reticulum
Localization Within Membrane
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Carrier Chaperone
Intracellular Protein Localization
Nucleoplasm
Post-embryonic Development
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Protein Stabilization
Cotranslational Protein Targeting To Membrane
Regulation Of Mitotic Cell Cycle
Outer Kinetochore
Cellular Response To Stress
Response To Stress
Synaptonemal Complex Assembly
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Mitotic Nuclear Division
Synaptonemal Complex Organization
Negative Regulation Of Protein Catabolic Process
Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint Signaling
Chromosome Organization
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Nuclear Division
Negative Regulation Of Proteolysis
Mismatch Repair
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Intracellular Protein Transmembrane Transport
Negative Regulation Of Mitotic Metaphase/anaphase Transition
Mitotic Cell Cycle Phase Transition
Negative Regulation Of Epithelial Cell Proliferation
Mature Chylomicron
Lipid Homeostasis
Cellular Localization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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