SEC63

Description		SEC63 protein translocation regulator
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sec62/Sec63 Complex
	Molecular Function	RNA Binding Protein Binding Protein Transmembrane Transporter Activity Signaling Receptor Activity
	Biological Process	Liver Development Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Transport Post-translational Protein Targeting To Membrane, Translocation Nitrogen Cycle Metabolic Process
Pathways
Drugs
Diseases		Polycystic liver disease
GWAS		Graft survival time in renal transplantation (donor effect) x APOL1 genotype interaction ( 32080893)
Interacting Genes		5 interacting genes: HSPA5 MEOX2 RNF10 SEC61B SEC62
Entrez ID		11231
HPRD ID		09783
Ensembl ID		ENSG00000025796
Uniprot IDs		A0A0S2Z5M1 Q9UGP8
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Targeting To Membrane, Translocation Intracellular Protein Transmembrane Transport Protein Transmembrane Transport ERAD Pathway Proteasomal Protein Catabolic Process Ribosome Binding Regulation Of Protein Folding In Endoplasmic Reticulum Intracellular Protein Transport Endoplasmic Reticulum Sec Complex Protein Catabolic Process Cerebellum Structural Organization Proteolysis Involved In Protein Catabolic Process Regulation Of ATF6-mediated Unfolded Protein Response Epidermal Growth Factor Binding Regulation Of Protein Folding Maintenance Of Protein Localization In Endoplasmic Reticulum Macromolecule Catabolic Process PERK-mediated Unfolded Protein Response Response To Endoplasmic Reticulum Stress ER Overload Response Endoplasmic Reticulum Membrane Endoplasmic Reticulum Chaperone Complex Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Transport IRE1-mediated Unfolded Protein Response Transmembrane Transport Cerebellar Purkinje Cell Layer Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of Transcription By RNA Polymerase II Intracellular Transport Proteolysis Negative Regulation Of IRE1-mediated Unfolded Protein Response Somite Specification Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Establishment Of Protein Localization Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Misfolded Protein Binding Segment Specification Somite Development Cotranslational Protein Targeting To Membrane Negative Regulation Of Glial Cell Proliferation Retrograde Protein Transport, ER To Cytosol Anatomical Structure Arrangement
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