AKAP13 and DYT10

Number of citations of the paper that reports this interaction (PMID 15383279)
51

Data Source:
BioGRID (pull down)

		AKAP13	DYT10
Gene Name		A kinase (PRKA) anchor protein 13	dystonia 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	CAMP-dependent Protein Kinase Activity Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding Protein Complex Scaffold Metal Ion Binding Protein Kinase A Binding
	Biological Process	Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Nuclear Export Apoptotic Signaling Pathway Regulation Of Glucocorticoid Mediated Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Central corneal thickness ( 20719862) Corneal structure ( 23291589)
Protein-Protein Interactions		20 interactors: CTNNAL1 DYT10 ESR1 ESR2 GNA12 GNAQ MAP1LC3A PPARA PRKACA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB THRA YWHAB YWHAE YWHAG YWHAZ	14 interactors: AKAP13 BTG2 CACYBP CYTH2 DAB2 GRM5 IFRD1 NFE2L2 NOXA1 PARK2 SATB1 SPAG1 STXBP1 XK
Entrez ID		11214	50818
HPRD ID		05253
Ensembl ID		ENSG00000170776
Uniprot IDs		B0AZU4 Q12802
PDB IDs		2DRN 2LG1
Enriched GO Terms of Interacting Partners?		Cell Communication Signal Transduction Cellular Response To Stimulus Cellular Response To Organic Substance Signaling Cellular Response To Hormone Stimulus Regulation Of Intracellular Transport Regulation Of Establishment Of Protein Localization Response To Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Localization Response To Organic Substance Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Steroid Hormone Mediated Signaling Pathway Response To Hormone Positive Regulation Of Intracellular Transport Intracellular Signal Transduction Regulation Of Cellular Localization Hormone-mediated Signaling Pathway Positive Regulation Of Phospholipase C Activity Rho Protein Signal Transduction Positive Regulation Of Mitochondrion Organization Transcription Initiation From RNA Polymerase II Promoter Apoptotic Signaling Pathway Cellular Response To Steroid Hormone Stimulus Wound Healing Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Platelet Activation Apoptotic Process Cellular Response To Organic Cyclic Compound Regulation Of Signaling Programmed Cell Death Positive Regulation Of Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Phospholipase Activity Response To Wounding Positive Regulation Of Lipase Activity Ras Protein Signal Transduction Blood Coagulation Cell Death Death Neurotrophin Signaling Pathway Hemostasis DNA-templated Transcription, Initiation Regulation Of Mitochondrion Organization Negative Regulation Of Kinase Activity	Negative Regulation Of Cell Death Regulation Of Cell Death Positive Regulation Of Metabolic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Learning Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Muscle Structure Development Negative Regulation Of Neuron Death Cell Differentiation Regulation Of Synaptic Vesicle Transport Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Oxidative Stress Multicellular Organismal Development Regulation Of Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signaling Learning Or Memory Anatomical Structure Development Regulation Of Neuron Death Cognition Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Adult Somatic Muscle Development Regulation Of Synaptic Transmission Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Neurotransmitter Secretion Striated Muscle Tissue Development Muscle Cell Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Signaling Muscle Tissue Development Regulation Of Kinase Activity System Development Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Protein Linear Polyubiquitination Myoblast Fate Determination Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Protein Stabilization
Tagcloud ?		anchoring assume bifunctional bundle causation chair crisis dbl deregulated dh dynamical explains gdp gef gtpase guanine helical hyperactive lbc linker mediation onco pleckstrin possessing rhoa rigid scattering seat solitary
Tagcloud (Difference) ?		anchoring assume bifunctional bundle causation chair crisis dbl deregulated dh dynamical explains gdp gef gtpase guanine helical hyperactive lbc linker mediation onco pleckstrin possessing rhoa rigid scattering seat solitary
Tagcloud (Intersection) ?