DYT10 and GRM5

Number of citations of the paper that reports this interaction (PMID 23152621)
0

Data Source:
BioGRID (enzymatic study)

		DYT10	GRM5
Gene Name		dystonia 10	glutamate receptor, metabotropic 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome Astrocyte Projection
	Molecular Function		G-protein Coupled Receptor Activity Glutamate Receptor Activity A2A Adenosine Receptor Binding
	Biological Process		Activation Of MAPKKK Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Locomotory Behavior Negative Regulation Of Locomotion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Synaptic Transmission, Glutamatergic
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			Acamprosate Rufinamide
Diseases
GWAS			Attention deficit hyperactivity disorder ( 22012869) Tanning ( 19340012)
Protein-Protein Interactions		14 interactors: AKAP13 BTG2 CACYBP CYTH2 DAB2 GRM5 IFRD1 NFE2L2 NOXA1 PARK2 SATB1 SPAG1 STXBP1 XK	19 interactors: CALM1 CALM2 CALM3 DYT10 EFNB2 FLNA GPRASP1 GRASP HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1
Entrez ID		50818	2915
HPRD ID			04980
Ensembl ID			ENSG00000168959
Uniprot IDs			A8K5P7 P41594
PDB IDs			3LMK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Death Regulation Of Cell Death Positive Regulation Of Metabolic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Learning Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Muscle Structure Development Negative Regulation Of Neuron Death Cell Differentiation Regulation Of Synaptic Vesicle Transport Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Oxidative Stress Multicellular Organismal Development Regulation Of Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signaling Learning Or Memory Anatomical Structure Development Regulation Of Neuron Death Cognition Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Adult Somatic Muscle Development Regulation Of Synaptic Transmission Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Neurotransmitter Secretion Striated Muscle Tissue Development Muscle Cell Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Signaling Muscle Tissue Development Regulation Of Kinase Activity System Development Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Protein Linear Polyubiquitination Myoblast Fate Determination Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Protein Stabilization	Platelet Activation Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Blood Coagulation Hemostasis Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Dephosphorylation Regulation Of Cellular Response To Insulin Stimulus Phototransduction, Visible Light Signal Transduction Synaptic Transmission Cellular Response To Growth Factor Stimulus Activation Of Adenylate Cyclase Activity Cell-cell Signaling Response To Growth Factor Detection Of Visible Light Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Light Stimulus Phototransduction Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Transport Signaling Regulation Of High Voltage-gated Calcium Channel Activity Intracellular Signal Transduction Cell Communication
Tagcloud ?			asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Difference) ?			asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm1 grm2 grm3 grm4 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Intersection) ?