CHKA and FCHSD2

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		CHKA	FCHSD2
Gene Name		choline kinase alpha	FCH and double SH3 domains 2
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Choline Kinase Activity Cholinesterase Activity Ethanolamine Kinase Activity Signal Transducer Activity ATP Binding Drug Binding Choline Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Lipid Transport Signal Transduction Phosphorylation Choline Metabolic Process Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways		Synthesis of PC Metabolism of lipids and lipoproteins Synthesis of PE Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS			Crohn's disease ( 23266558)
Protein-Protein Interactions		6 interactors: APP DEPTOR FCHSD2 PSEN2 RCC1 SKP2	25 interactors: ABCF3 C2orf73 C9orf78 CASK CCDC158 CCDC85B CCT2 CFAP36 CHKA DAPP1 FAM9B HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 MSL1 MTUS2 PDE4DIP SH3BGR SRP72 VCPIP1 WAS WASL
Entrez ID		1119	9873
HPRD ID		00327	13321
Ensembl ID		ENSG00000110721	ENSG00000137478
Uniprot IDs		P35790	E9PG19 O94868
PDB IDs		2CKO 2CKP 2CKQ 2I7Q 3F2R 3G15 3ZM9 4BR3 4DA5	2DL5 2DL7
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Receptor Activity Regulation Of Protein Kinase Activity Notch Signaling Pathway Regulation Of Kinase Activity Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Cell-matrix Adhesion Synaptic Growth At Neuromuscular Junction G1/S Transition Of Mitotic Cell Cycle Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Mitotic Cell Cycle Phase Transition Learning Or Memory Cell Cycle Phase Transition Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Axon Choice Point Recognition Cognition Cellular Calcium Ion Homeostasis Regulation Of Phosphorylation Calcium Ion Homeostasis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Ran GTPase Activity Neuron Remodeling Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Amyloid Precursor Protein Catabolic Process Positive Regulation Of Catalytic Activity Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Cellular Metal Ion Homeostasis Regulation Of Mitotic Cell Cycle Cellular Cation Homeostasis Forebrain Development	Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Arp2/3 Complex-mediated Actin Nucleation Endocytosis Regulation Of Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Toxin Transport Cellular Response To Interleukin-4 Vesicle-mediated Transport Response To Interleukin-4 Regulation Of Protein Folding In Endoplasmic Reticulum Protein Complex Assembly Phagocytosis Actin Filament-based Movement Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Golgi Organization Endoplasmic Reticulum Membrane Fusion Negative Regulation Of Membrane Tubulation Cerebellum Structural Organization Transport Actin Polymerization Or Depolymerization Cellular Protein Complex Assembly Zonula Adherens Maintenance Vesicle Transport Along Actin Filament Cellular Component Assembly Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Golgi Reassembly Dentinogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Axon Guidance Protein Localization To Endoplasmic Reticulum Positive Regulation Of Clathrin-mediated Endocytosis Movement Of Cell Or Subcellular Component Response To Unfolded Protein Immune Response-regulating Signaling Pathway Choline Metabolic Process Golgi Inheritance Protein K11-linked Deubiquitination
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