CHKA and TRIM25

Number of citations of the paper that reports this interaction (PubMedID 37011206)
32

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		CHKA	TRIM25
Description		choline kinase alpha	tripartite motif containing 25
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GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body
	Molecular Function	Nucleotide Binding Choline Kinase Activity Cholinesterase Activity Ethanolamine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Lipid Transport Phospholipid Biosynthetic Process Cellular Response To Glucose Starvation Lipid Droplet Disassembly	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Response To Oxidative Stress MRNA Transcription Protein Ubiquitination Viral Release From Host Cell Regulation Of Protein Localization Response To Vitamin D Cellular Response To Oxidative Stress ERAD Pathway RIG-I Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Protein K48-linked Ubiquitination Antiviral Innate Immune Response Cellular Response To Leukemia Inhibitory Factor
Pathways		Synthesis of PC Synthesis of PE	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Lipoprotein (a) levels ( 33730874)	Height ( 18391951) Lean body mass ( 28552196)
Interacting Genes		8 interacting genes: APP DEPTOR ENO1 FCHSD2 PSEN2 RCC1 SKP2 TRIM25	77 interacting genes: AMFR APC CASP7 CEBPA CHKA CRK DDX3X DICER1 EIF4G3 ERCC2 ERG ESR1 G3BP1 G3BP2 GABARAP GABARAPL1 GABARAPL2 GATA1 GRIK2 LINC00955 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K13 MEIS2 MIR1-1 MIR155 MIR16-2 MIR19B2 MIR205 MIR206 MIR21 MIR221 MIR25 MIR29A MIR29B1 MIR34A MIR363 MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MTA1 OTUB2 PAX2 PIK3R1 PITX2 PLAAT4 PTEN RBCK1 RIPK3 RNF31 SFN SLC26A4-AS1 STK11 STK38 SUMO2 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 YWHAQ ZBTB7A ZNF24
Entrez ID		1119	7706
HPRD ID		00327	02711
Ensembl ID		ENSG00000110721	ENSG00000121060
Uniprot IDs		P35790	Q14258
PDB IDs		2CKO 2CKP 2CKQ 2I7Q 3F2R 3G15 3ZM9 4BR3 4CG8 4CG9 4CGA 4DA5 5AFV 5EQE 5EQP 5EQY 5FTG 5FUT 5W6O 7A04 7A06 7NB1 7NB2 7NB3 8BI5 8BI6	4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Phosphorus Metabolic Process Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Recycling Endosome Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of ATP Metabolic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Clathrin-coated Pit Response To External Biotic Stimulus Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Growth Factor Receptor Binding Main Axon Regulation Of Cellular Response To Stress Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Response To Other Organism Astrocyte Activation Involved In Immune Response Microglia Development Regulation Of Intracellular Signal Transduction Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Mitotic Cell Cycle Phase Transition Cell Cycle G1/S Phase Transition Viral Process Sulfate Binding G1/S Transition Of Mitotic Cell Cycle Phosphopyruvate Hydratase Complex Response To Virus Phosphopyruvate Hydratase Activity	Post-transcriptional Gene Silencing RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nitrogen Starvation MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Phosphatidylethanolamine Binding Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction MRNA 3'-UTR Binding Cellular Response To Stress Negative Regulation Of Gene Expression Post-translational Protein Modification Response To Stress Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Translation Positive Regulation Of Protein Polyubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Regulation Of RNA Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Motility Negative Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Locomotion
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