KDELR2 and KAT2A

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		KDELR2	KAT2A
Description		KDEL endoplasmic reticulum protein retention receptor 2	lysine acetyltransferase 2A
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle	Histone Acetyltransferase Complex SAGA Complex Chromatin Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle ATAC Complex
	Molecular Function	KDEL Sequence Binding ER Retention Sequence Binding	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding N-acetyltransferase Activity Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein Phosphatase Binding Histone Deacetylase Binding Histone H3K9 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity Histone Glutaryltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Protein Retention In ER Lumen Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Maintenance Of Protein Localization In Endoplasmic Reticulum	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Neural Tube Closure Gluconeogenesis Regulation Of DNA Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Heart Development Long-term Memory Regulation Of Gene Expression Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Multicellular Organism Growth Protein Modification Process Regulation Of RNA Splicing Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Negative Regulation Of Centriole Replication Fibroblast Proliferation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Regulation Of Cell Division Regulation Of Cell Cycle Limb Development Regulation Of Cartilage Development Regulation Of Small Molecule Metabolic Process Cellular Response To Tumor Necrosis Factor Peptidyl-lysine Glutarylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis Formation of WDR5-containing histone-modifying complexes Formation of paraxial mesoderm
Drugs			Coenzyme A
Diseases
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Lymphocyte percentage of white cells ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Red cell distribution width ( 32888494) Ulcerative colitis ( 28067908)	Coronary artery disease ( 29212778 33020668) Inflammatory bowel disease ( 26278503) Mean reticulocyte volume ( 32888494) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)
Interacting Genes		22 interacting genes: AKT1 BECN1 CCND2 CD44 CDK4 CDK6 CDKN2B EPHA2 ERBB2 FGFR4 GRM1 IGF1R KAT2A LATS2 MAP2K3 MET MYC NF2 PDGFRA RASSF1 STK11 TTYH2	67 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPA CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL ECHS1 EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-4 H3C1 H3C14 H4C14 H4C16 H4C7 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PRKDC PYGO2 RASSF1 RBPJ RELA RPA1 SIRT2 SNCA STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6
Entrez ID		11014	2648
HPRD ID		06598	03807
Ensembl ID		ENSG00000136240	ENSG00000108773
Uniprot IDs		P33947	Q92830
PDB IDs			1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P 8E6O 8H65 8H66 8H6C 8H6D
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Signal Transduction Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Transferase Activity Regulation Of Signal Transduction ATP Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Receptor Complex Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Protein Phosphorylation Regulation Of Catalytic Activity Nucleotide Binding Regulation Of Epithelial Cell Proliferation Phosphorylation Protein Autophosphorylation Positive Regulation Of Cellular Component Organization Peptidyl-tyrosine Phosphorylation Positive Regulation Of Fibroblast Proliferation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Mitotic Cell Cycle Phase Transition Positive Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Cell Cycle Phase Transition Positive Regulation Of Catalytic Activity Negative Regulation Of Intracellular Signal Transduction Animal Organ Development Intracellular Signal Transduction Protein Serine Kinase Activity Cyclin D2-CDK4 Complex Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation	Nucleus Nucleoplasm Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Structural Constituent Of Chromatin Nucleosome Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Protein Heterodimerization Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Hemopoiesis DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Mitotic Cell Cycle Phase Transition Mononuclear Cell Differentiation Nucleosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Cell Cycle Phase Transition Chromosome
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