PKIG and DYNLL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PKIG	DYNLL2
Description		cAMP-dependent protein kinase inhibitor gamma	dynein light chain LC8-type 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Import Into Nucleus	Microtubule-based Process
Pathways			Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 28067908) Pancreatic cancer ( 29422604) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576)
Interacting Genes		3 interacting genes: DYNLL1 DYNLL2 MEOX2	30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1
Entrez ID		11142	140735
HPRD ID		05379	06489
Ensembl ID		ENSG00000168734	ENSG00000264364
Uniprot IDs		Q549H9 Q9Y2B9	Q96FJ2
PDB IDs			2XQQ 3P8M 4D07 7CNU
Enriched GO Terms of Interacting Partners?		Cytoplasmic Dynein Complex Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex Ciliary Tip Scaffold Protein Binding Myosin V Complex Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Microtubule Cytoskeleton Somite Specification Microtubule Protein-containing Complex Binding Nitric-oxide Synthase Regulator Activity 9+0 Non-motile Cilium Negative Regulation Of DNA-templated DNA Replication Segment Specification Somite Development Negative Regulation Of Nitric Oxide Biosynthetic Process Intraciliary Retrograde Transport DNA Strand Resection Involved In Replication Fork Processing Cilium Negative Regulation Of DNA Replication Centrosome Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus COP9 Signalosome Microtubule-based Process	Microtubule Binding
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