NGLY1 and UBXN2B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NGLY1	UBXN2B
Gene Name		N-glycanase 1	UBX domain protein 2B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding	Protein Phosphatase Type 1 Regulator Activity Ubiquitin Binding
	Biological Process	Glycoprotein Catabolic Process	Autophagic Vacuole Assembly Golgi Organization Nuclear Envelope Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Membrane Fusion
Pathways
Drugs
Diseases
GWAS			Narcolepsy with cataplexy ( 23496005)
Protein-Protein Interactions		12 interactors: APP FAF1 GUCD1 NSFL1C RAD23A RAD23B SRPK2 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP	6 interactors: CRX INCA1 MEOX1 NGLY1 VAT1L VCP
Entrez ID		55768	137886
HPRD ID		10118	18973
Ensembl ID		ENSG00000151092	ENSG00000215114
Uniprot IDs		Q96IV0	E5RJ36 Q14CS0
PDB IDs		2CCQ 2CM0
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Nuclear Envelope Reassembly Regulation Of Protein Catabolic Process Nucleus Organization Response To Stress Cellular Response To Stress Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Proteolysis Autophagic Vacuole Assembly Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stimulus Macroautophagy Nuclear Envelope Organization Regulation Of Viral Genome Replication Nuclear Speck Organization Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Viral Process Golgi Organization Protein Metabolic Process Nucleotide-excision Repair Regulation Of Metabolic Process Synaptic Growth At Neuromuscular Junction Nucleotide-excision Repair, DNA Damage Recognition Cellular Component Assembly Vacuole Organization Collateral Sprouting In Absence Of Injury Membrane Fusion Cellular Response To Starvation Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Collateral Sprouting Axon Midline Choice Point Recognition Retrograde Protein Transport, ER To Cytosol	Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Photoreceptor Cell Differentiation Sclerotome Development Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Deubiquitination Somite Specification Protein Hexamerization Aggresome Assembly Translesion Synthesis Glycoprotein Catabolic Process Hematopoietic Stem Cell Differentiation
Tagcloud ?		ablation acetylglucosaminidase catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo engase erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded phenotypic pngase precise prone restored unconventional underscores
Tagcloud (Difference) ?		ablation acetylglucosaminidase catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo engase erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded phenotypic pngase precise prone restored unconventional underscores
Tagcloud (Intersection) ?