NGLY1 and RAD23A

Number of citations of the paper that reports this interaction (PMID 22575648)
2

Data Source:
BioGRID (two hybrid, x-ray crystallography)

		NGLY1	RAD23A
Gene Name		N-glycanase 1	RAD23 homolog A (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Proteasome Complex Nucleoplasm Cytoplasm
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Binding Ubiquitin-specific Protease Binding
	Biological Process	Glycoprotein Catabolic Process	Nucleotide-excision Repair Viral Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: APP FAF1 GUCD1 NSFL1C RAD23A RAD23B SRPK2 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP	50 interactors: A2M ADRM1 ANKRD40 ATXN3 ATXN7 CCNA2 CCNB1 CDC37 CREBBP DBI ECSIT EP300 EWSR1 FAM188A FILIP1 GTF2H1 IFIT3 IFIT5 LOXL4 MAST1 MDM2 MPG NGLY1 PARK2 PDE6D PHAX PI4K2A PSEN1 PSMC5 PSMD4 RNF115 RNF32 RPN1 SQSTM1 TRAF2 TRAF5 TRIM54 TRIP6 UBB UBE2D1 UBE2L3 UBE2L6 UBE3A UBL7 UBQLN4 USP25 VAV2 XPC ZBTB44 ZBTB8A
Entrez ID		55768	5886
HPRD ID		10118	07191
Ensembl ID		ENSG00000151092	ENSG00000179262
Uniprot IDs		Q96IV0	A8K1J3 P54725
PDB IDs		2CCQ 2CM0	1DV0 1F4I 1IFY 1OQY 1P98 1P9D 1QZE 1TP4 1ZO6 2WYQ
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Nuclear Envelope Reassembly Regulation Of Protein Catabolic Process Nucleus Organization Response To Stress Cellular Response To Stress Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Proteolysis Autophagic Vacuole Assembly Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stimulus Macroautophagy Nuclear Envelope Organization Regulation Of Viral Genome Replication Nuclear Speck Organization Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Viral Process Golgi Organization Protein Metabolic Process Nucleotide-excision Repair Regulation Of Metabolic Process Synaptic Growth At Neuromuscular Junction Nucleotide-excision Repair, DNA Damage Recognition Cellular Component Assembly Vacuole Organization Collateral Sprouting In Absence Of Injury Membrane Fusion Cellular Response To Starvation Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Collateral Sprouting Axon Midline Choice Point Recognition Retrograde Protein Transport, ER To Cytosol	Cellular Macromolecule Catabolic Process Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Catabolic Process Protein Polyubiquitination Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Cellular Response To Stress Response To Stress Cellular Protein Modification Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Ligase Activity Positive Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Mitotic DNA Damage Checkpoint Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Cellular Response To Oxygen Levels Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Catalytic Activity Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Innate Immune Response
Tagcloud ?		ablation acetylglucosaminidase catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo engase erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded phenotypic pngase precise prone restored unconventional underscores	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Difference) ?		ablation acetylglucosaminidase catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo engase erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded phenotypic pngase precise prone restored unconventional underscores	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Intersection) ?