NLRP2

Description		NLR family pyrin domain containing 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Cytoplasm Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Pyrin Domain Binding
	Biological Process	Immune System Process Apoptotic Process Inflammatory Response Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Regulation Of Inflammatory Response Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Venous thromboembolism ( 31420334)
Interacting Genes		4 interacting genes: APP CARD8 FAF1 PYDC2
Entrez ID		55655
HPRD ID		14805
Ensembl ID		ENSG00000022556
Uniprot IDs		A8K9G6 J3KN39 Q9NX02
PDB IDs		9C6V 9C6W 9C6X
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Inflammatory Response Negative Regulation Of Cell Communication Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Amyloid-beta Complex Innate Immune Response Growth Cone Lamellipodium Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction CARD8 Inflammasome Complex Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Defense Response To Symbiont Defense Response To Other Organism Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Acetylcholine Receptor Activator Activity Regulation Of Defense Response Positive Regulation Of Apoptotic Signaling Pathway Lipoprotein Particle Regulation Of Cytokine Production Positive Regulation Of Protein Import NACHT Domain Binding PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Inflammatory Response Endosome To Plasma Membrane Transport Vesicle Programmed Cell Death Positive Regulation Of Endothelin Production Growth Cone Filopodium Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development
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