NLRP2 and PYDC2

Number of citations of the paper that reports this interaction (PubMedID 17178784)
36

Data Source:
HPRD (in vitro, in vivo)

		NLRP2	PYDC2
Description		NLR family pyrin domain containing 2	pyrin domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Cytoplasm Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Pyrin Domain Binding	Protein Binding
	Biological Process	Immune System Process Apoptotic Process Inflammatory Response Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Regulation Of Inflammatory Response Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Immune System Process Inflammatory Response Negative Regulation Of Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Venous thromboembolism ( 31420334)	Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		4 interacting genes: APP CARD8 FAF1 PYDC2	2 interacting genes: NLRP2 PYCARD
Entrez ID		55655	152138
HPRD ID		14805	19279
Ensembl ID		ENSG00000022556	ENSG00000253548
Uniprot IDs		A8K9G6 J3KN39 Q9NX02	Q56P42
PDB IDs		9C6V 9C6W 9C6X
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Inflammatory Response Negative Regulation Of Cell Communication Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Amyloid-beta Complex Innate Immune Response Growth Cone Lamellipodium Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction CARD8 Inflammasome Complex Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Defense Response To Symbiont Defense Response To Other Organism Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Acetylcholine Receptor Activator Activity Regulation Of Defense Response Positive Regulation Of Apoptotic Signaling Pathway Lipoprotein Particle Regulation Of Cytokine Production Positive Regulation Of Protein Import NACHT Domain Binding PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Inflammatory Response Endosome To Plasma Membrane Transport Vesicle Programmed Cell Death Positive Regulation Of Endothelin Production Growth Cone Filopodium Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development	Pyrin Domain Binding Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Myosin I Binding NLRP6 Inflammasome Complex Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II AIM2 Inflammasome Complex Myeloid Dendritic Cell Activation Involved In Immune Response Regulation Of Inflammatory Response Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Positive Regulation Of Cytokine Production NLRP1 Inflammasome Complex Interleukin-6 Receptor Binding IkappaB Kinase Complex Macropinocytosis Inflammatory Response Cysteine-type Endopeptidase Activator Activity Pinocytosis Innate Immune Response BMP Receptor Binding Tropomyosin Binding Canonical Inflammasome Complex Negative Regulation Of Interferon-beta Production Defense Response To Symbiont Defense Response To Other Organism Negative Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Regulation Of Defense Response Apoptotic Process Regulation Of Antigen Processing And Presentation NLRP3 Inflammasome Complex Assembly Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Release Of Cytochrome C From Mitochondria Programmed Cell Death Cell Death Myeloid Dendritic Cell Activation Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Defense Response To Virus By Host Response To Other Organism Canonical Inflammasome Complex Assembly Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Activated T Cell Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?