KATNA1 and DCAF1

Number of citations of the paper that reports this interaction (PubMedID 19287380)
33

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		KATNA1	DCAF1
Description		katanin catalytic subunit A1	DDB1 and CUL4 associated factor 1
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Katanin Complex Microtubule Cytoskeleton Midbody Mitotic Spindle Mitotic Spindle Pole	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Protein Heterodimerization Activity	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nuclear Estrogen Receptor Binding Protein Serine Kinase Activity Histone H2AT120 Kinase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Lung cancer ( 27393504) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Asthma ( 32296059)
Interacting Genes		11 interacting genes: APP CAMSAP3 CLK1 CLU DCAF1 DYNC1H1 DYRK2 KATNB1 LIPE OGT PAFAH1B1	25 interacting genes: ATM ATR CCP110 CD274 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF IRF1 KATNA1 LATS1 LATS2 NF2 PLK4 PRKDC PWP1 PYGO2 RAG1 TET2 TP53 UBE2D2 UBE2D3 USP2
Entrez ID		11104	9730
HPRD ID		05986	11674
Ensembl ID		ENSG00000186625	ENSG00000145041
Uniprot IDs		A8K7S5 O75449	Q9Y4B6
PDB IDs		5ZQL 5ZQM	3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45 6ZUE 6ZX9 7OKQ 7SSE 7UFV 7V7B 7V7C 8F8E 8OG5 8OG6 8OG7 8OG8 8OG9 8OGA 8OGB 8OGC 8OO5 8OOD 9B9H 9B9T 9B9W 9BA2 9BHR 9BHS 9C1Q 9D4E 9DLW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nitric Oxide Biosynthetic Process Transport Along Microtubule Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Nitric Oxide Metabolic Process Microtubule-based Movement Regulation Of Microtubule Cytoskeleton Organization Regulation Of Nitric Oxide Biosynthetic Process Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Regulation Of Nitric Oxide Metabolic Process Cytoplasmic Microtubule Organization Cytoskeleton Axo-dendritic Transport Regulation Of Microtubule-based Process Centrosome Intracellular Signal Transduction Regulation Of Amyloid Fibril Formation Protein Heterodimerization Activity Microtubule Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Retrograde Axonal Transport Ether Lipid Metabolic Process Dynein Complex Binding Regulation Of Supramolecular Fiber Organization Protein-containing Complex Growth Cone Microtubule-based Process Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of MiRNA Transcription Nuclear Migration Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Microglial Cell Activation Microtubule Cytoskeleton Organization Nucleus Localization Hemopoiesis Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Dynein Intermediate Chain Binding Supramolecular Fiber Organization Regulation Of Toll-like Receptor Signaling Pathway Nuclear Estrogen Receptor Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Cytoskeleton Organization	Histone H2AXS139 Kinase Activity Nucleus Chromatin Organization Regulation Of Cell Cycle Positive Regulation Of Cellular Component Biogenesis DNA Binding DNA Repair Somatic Cell DNA Recombination Chromosome Organization Nucleoplasm DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Telomere Organization Response To Gamma Radiation Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Signal Transduction In Response To DNA Damage V(D)J Recombination Chromatin Remodeling Centrosome DNA-dependent Protein Kinase Activity Chromosome, Telomeric Region Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Cellular Response To Gamma Radiation Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein-containing Complex Assembly Pre-B Cell Allelic Exclusion DNA Damage Response DNA Damage Checkpoint Signaling Macromolecule Metabolic Process ATP Binding Nucleotide Binding Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Regulation Of T Cell Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Processing B Cell Lineage Commitment Regulation Of Protein-containing Complex Assembly Regulation Of Organelle Assembly Regulation Of Telomere Maintenance Via Telomerase T Cell Differentiation In Thymus Response To Radiation Regulation Of Hippo Signaling Somitogenesis
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