KATNA1 and DYNC1H1

Number of citations of the paper that reports this interaction (PMID 16203747)
30

Data Source:
BioGRID (pull down, affinity chromatography technology)

		KATNA1	DYNC1H1
Gene Name		katanin p60 (ATPase containing) subunit A 1	dynein, cytoplasmic 1, heavy chain 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Lipid Particle Centrosome Microtubule Organizing Center Spindle Microtubule Plasma Membrane Axon Growth Cone Midbody Neuronal Cell Body	Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Membrane Filopodium Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Dynein Binding Protein Heterodimerization Activity	Microtubule Motor Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding Dynein Light Intermediate Chain Binding
	Biological Process	Microtubule Bundle Formation Neuron Migration Mitotic Nuclear Division Protein Localization Metabolic Process Negative Regulation Of Neuron Projection Development Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transport Organelle Organization Microtubule-based Movement Mitotic Spindle Organization Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CLU DYNC1H1 DYRK2 KATNB1 LIPE PAFAH1B1 VPRBP	14 interactors: BRCA1 DISC1 DYNLL1 EGFR FAM46A KATNA1 KATNB1 NDEL1 PRKCD SMAD2 SNCA TNIK YWHAG YWHAQ
Entrez ID		11104	1778
HPRD ID		05986	02524
Ensembl ID		ENSG00000186625	ENSG00000197102
Uniprot IDs		A8K7S5 O75449	Q14204
PDB IDs			2BOR 2BOT
Enriched GO Terms of Interacting Partners?		Microtubule-based Movement Cell Competition In A Multicellular Organism Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Histone H2A-T120 Phosphorylation Regulation Of Neuronal Signal Transduction G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Neurofibrillary Tangle Assembly Organelle Organization Mitotic Cell Cycle Process Establishment Of Centrosome Localization Mitotic Chromosome Movement Towards Spindle Pole Diacylglycerol Catabolic Process Mitotic Cell Cycle Microtubule-based Process Central Nervous System Myelin Maintenance Intrinsic Apoptotic Signaling Pathway Regulation Of Tau-protein Kinase Activity Positive Regulation Of Microtubule Depolymerization Platelet Activating Factor Metabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Neuron Projection Development Immune System Process Long-chain Fatty Acid Catabolic Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Gliogenesis Lipid Catabolic Process Corpus Callosum Morphogenesis Mitotic Cell Cycle Phase Transition Osteoclast Development Positive Regulation Of Beta-amyloid Formation Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Protein Oligomerization Positive Regulation Of Cell Projection Organization Negative Regulation Of Beta-amyloid Formation Cytoplasmic MRNA Processing Body Assembly Retrograde Axon Cargo Transport Microtubule Severing Mitotic Nuclear Division Nuclear Migration Establishment Of Organelle Localization Positive Regulation Of Neuron Differentiation Leukocyte Differentiation Positive Regulation Of Glycogen Biosynthetic Process Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Alcohol Metabolic Process	Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway Developmental Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Intracellular Transport Regulation Of Cell Development Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Neuron Differentiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Cell Death Cell Cycle Process Nervous System Development Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitotic Cell Cycle Process Cellular Localization Regulation Of Neurogenesis Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Neuron Projection Development Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Transport Mitotic Cell Cycle Positive Regulation Of Organelle Organization Microtubule-based Process Protein Localization Regulation Of Intracellular Transport Multicellular Organismal Development Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Mitochondrion Organization Anatomical Structure Development Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Response To DNA Damage Stimulus Apoptotic Process Generation Of Neurons Regulation Of Cell Differentiation Microtubule Severing Programmed Cell Death Organelle Organization System Development Positive Regulation Of Apoptotic Process
Tagcloud ?			200x customized dcx depths exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal
Tagcloud (Difference) ?			200x customized dcx depths exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal
Tagcloud (Intersection) ?