KATNA1 and KATNB1

Number of citations of the paper that reports this interaction (PubMedID 10751153)
0

Data Source:
HPRD (in vivo, in vitro)

		KATNA1	KATNB1
Description		katanin catalytic subunit A1	katanin regulatory subunit B1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Katanin Complex Microtubule Cytoskeleton Midbody Mitotic Spindle Mitotic Spindle Pole	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Katanin Complex Microtubule Cytoskeleton Membrane Axon Growth Cone Midbody Neuronal Cell Body
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Protein Heterodimerization Activity	Protein Binding Microtubule Binding Protein Heterodimerization Activity ATPase Regulator Activity Dynein Complex Binding
	Biological Process	Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	Protein Targeting Microtubule Depolymerization Negative Regulation Of Microtubule Depolymerization Mitotic Chromosome Movement Towards Spindle Pole Positive Regulation Of Neuron Projection Development Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Positive Regulation Of Apoptotic Process Microtubule Severing Cell Division
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Lung cancer ( 27393504) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)
Interacting Genes		11 interacting genes: APP CAMSAP3 CLK1 CLU DCAF1 DYNC1H1 DYRK2 KATNB1 LIPE OGT PAFAH1B1	7 interacting genes: CAMSAP3 DYNC1H1 KATNA1 PAFAH1B1 RXFP3 TGFBR1 XRN1
Entrez ID		11104	10300
HPRD ID		05986	04081
Ensembl ID		ENSG00000186625	ENSG00000140854
Uniprot IDs		A8K7S5 O75449	Q9BVA0
PDB IDs		5ZQL 5ZQM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nitric Oxide Biosynthetic Process Transport Along Microtubule Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Nitric Oxide Metabolic Process Microtubule-based Movement Regulation Of Microtubule Cytoskeleton Organization Regulation Of Nitric Oxide Biosynthetic Process Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Regulation Of Nitric Oxide Metabolic Process Cytoplasmic Microtubule Organization Cytoskeleton Axo-dendritic Transport Regulation Of Microtubule-based Process Centrosome Intracellular Signal Transduction Regulation Of Amyloid Fibril Formation Protein Heterodimerization Activity Microtubule Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Retrograde Axonal Transport Ether Lipid Metabolic Process Dynein Complex Binding Regulation Of Supramolecular Fiber Organization Protein-containing Complex Growth Cone Microtubule-based Process Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of MiRNA Transcription Nuclear Migration Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Microglial Cell Activation Microtubule Cytoskeleton Organization Nucleus Localization Hemopoiesis Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Dynein Intermediate Chain Binding Supramolecular Fiber Organization Regulation Of Toll-like Receptor Signaling Pathway Nuclear Estrogen Receptor Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Cytoskeleton Organization	Cytoplasmic Microtubule Organization Microtubule Retrograde Axonal Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cytoskeleton Organization Microtubule Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cell Cycle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Nuclear Migration Nucleus Localization Microtubule-based Transport Centrosome Dynein Intermediate Chain Binding Microtubule Binding Microtubule Cytoskeleton Regulation Of Microtubule-based Process Microtubule-based Process Establishment Of Spindle Localization Cytoplasmic Microtubule Positive Regulation Of Cell Cycle Axon Cytoplasm Spindle Localization Axonal Transport Cytoskeleton Organization Microtubule-based Movement Cellular Response To Puromycin Cellular Response To Cycloheximide Axo-dendritic Transport Cell Division Supramolecular Fiber Organization Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Sliding 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Astral Microtubule Ameboidal-type Cell Migration Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Central Region Of Growth Cone Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Replication Fork Protection Complex Zonula Adherens Maintenance Negative Regulation Of DNA Metabolic Process Cytoskeleton Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
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