KATNA1 and DYRK2

Number of citations of the paper that reports this interaction (PubMedID 19287380)
33

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		KATNA1	DYRK2
Description		katanin catalytic subunit A1	dual specificity tyrosine phosphorylation regulated kinase 2
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Katanin Complex Microtubule Cytoskeleton Midbody Mitotic Spindle Mitotic Spindle Pole	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Protein Heterodimerization Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Protein Serine Kinase Activity
	Biological Process	Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	Protein Phosphorylation Apoptotic Process DNA Damage Response Smoothened Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Lung cancer ( 27393504) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Malaria ( 31844061) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Peak height velocity ( 34047840) Systemic lupus erythematosus ( 28714469)
Interacting Genes		11 interacting genes: APP CAMSAP3 CLK1 CLU DCAF1 DYNC1H1 DYRK2 KATNB1 LIPE OGT PAFAH1B1	23 interacting genes: APP ATM DYRK4 EIF2B5 FBXW7 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9
Entrez ID		11104	8445
HPRD ID		05986	04606
Ensembl ID		ENSG00000186625	ENSG00000127334
Uniprot IDs		A8K7S5 O75449	Q92630
PDB IDs		5ZQL 5ZQM	3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J 7AKF 7AKH 7DG4 7DH3 7DH9 7DHC 7DHH 7DHK 7DHN 7DHO 7DHV 7DJO 7DL6 8HLT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nitric Oxide Biosynthetic Process Transport Along Microtubule Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Nitric Oxide Metabolic Process Microtubule-based Movement Regulation Of Microtubule Cytoskeleton Organization Regulation Of Nitric Oxide Biosynthetic Process Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Regulation Of Nitric Oxide Metabolic Process Cytoplasmic Microtubule Organization Cytoskeleton Axo-dendritic Transport Regulation Of Microtubule-based Process Centrosome Intracellular Signal Transduction Regulation Of Amyloid Fibril Formation Protein Heterodimerization Activity Microtubule Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Retrograde Axonal Transport Ether Lipid Metabolic Process Dynein Complex Binding Regulation Of Supramolecular Fiber Organization Protein-containing Complex Growth Cone Microtubule-based Process Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of MiRNA Transcription Nuclear Migration Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Microglial Cell Activation Microtubule Cytoskeleton Organization Nucleus Localization Hemopoiesis Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Dynein Intermediate Chain Binding Supramolecular Fiber Organization Regulation Of Toll-like Receptor Signaling Pathway Nuclear Estrogen Receptor Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Cytoskeleton Organization	Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Wnt Signaling Pathway Regulation Of Establishment Of Protein Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Nucleus Negative Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Determination Of Adult Lifespan Cellular Response To Reactive Oxygen Species Regulation Of Canonical Wnt Signaling Pathway Main Axon Cellular Response To Stress DNA Binding Proteasomal Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Cellular Response To Manganese Ion Regulation Of Protein Localization To Nucleus Regulation Of Cellular Response To Stress Identical Protein Binding Response To Reactive Oxygen Species DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Distribution Of Mitochondria Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Microtubule Severing Response To Metal Ion Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromosome, Telomeric Region Response To Oxidative Stress Positive Regulation Of Neuron Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Stability Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Proteolysis Response To Manganese Ion Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Regulation Of Signal Transduction Replicative Senescence
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