WDR5 and KMT2C

Number of citations of the paper that reports this interaction (PMID 22266653)
13

Data Source:
BioGRID (unspecified method, x-ray crystallography, unspecified method)

		WDR5	KMT2C
Gene Name		WD repeat domain 5	lysine (K)-specific methyltransferase 2C
Image
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Histone Methyltransferase Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Nucleoplasm Histone Methyltransferase Complex
	Molecular Function	Protein Binding Histone Methyltransferase Activity (H3-K4 Specific) Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)	DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Poly(A) RNA Binding
	Biological Process	Skeletal System Development Chromatin Organization Transcription, DNA-templated Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Histone H3-K4 Methylation	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Intracellular Signal Transduction Histone H3-K4 Methylation
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: APP ATN1 CHD8 HIST1H1C HIST4H4 HSF2 IKBKG KMT2A KMT2B KMT2C MBIP MLLT1 POU5F1 PRMT5 PRNP RUSC1-AS1 SETD1A SETD1B SRPK2 SSX2IP TERF2IP TP53 ZXDC	7 interactors: HIST1H3A HIST2H3C JUN MAPK14 SMARCB1 TSC22D1 WDR5
Entrez ID		11091	58508
HPRD ID		10614	06016
Ensembl ID		ENSG00000196363	ENSG00000055609
Uniprot IDs		P61964	Q8NEZ4
PDB IDs		2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4IA9	2YSM 2YUK 3UVL 4ERY
Enriched GO Terms of Interacting Partners?		Gene Expression Chromatin Organization Regulation Of RNA Metabolic Process Chromosome Organization RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression Histone H3-K4 Methylation RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Methylation Histone Modification Chromatin Modification Cellular Nitrogen Compound Metabolic Process Protein Methylation Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Histone Lysine Methylation Peptidyl-lysine Methylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organelle Organization Methylation Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Chromosome Organization Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Regulation Of Transcription From RNA Polymerase II Promoter Neuron Apoptotic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Death Cellular Metabolic Process Histone H3-K4 Trimethylation DNA Conformation Change Regulation Of Organelle Organization Cellular Copper Ion Homeostasis Regulation Of Fibroblast Apoptotic Process	Gene Expression Positive Regulation By Host Of Viral Transcription DNA Methylation On Cytosine Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Wounding Interaction With Symbiont Nitrogen Compound Metabolic Process Chromatin Silencing Positive Regulation Of Viral Transcription Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway DNA Methylation TRIF-dependent Toll-like Receptor Signaling Pathway Transcription, DNA-templated MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Viral Transcription Methylation RNA Biosynthetic Process Blood Coagulation MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Viral Process Hemostasis Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Myeloid Cell Differentiation Toll-like Receptor 4 Signaling Pathway DNA Modification Positive Regulation Of Transcription, DNA-templated P38MAPK Cascade Cellular Response To Potassium Ion Starvation Regulation Of Metabolic Process Gene Silencing Toll-like Receptor Signaling Pathway Regulation Of Body Fluid Levels
Tagcloud ?		acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wrad	aacr aggressive ajuba candidate casp8 cdkn2a clin cscc disfiguring dominated drive driver drivers exome fat1 foundation hras inactivating lethal links mll3 mutational mutsig notch1 notch2 pard3 rasa1 res suppressors
Tagcloud (Difference) ?		acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wrad	aacr aggressive ajuba candidate casp8 cdkn2a clin cscc disfiguring dominated drive driver drivers exome fat1 foundation hras inactivating lethal links mll3 mutsig notch1 notch2 pard3 rasa1 res suppressors
Tagcloud (Intersection) ?		mutational