RIMS2 and CACNA1S

Number of citations of the paper that reports this interaction (PMID 14660679)
50

Data Source:
HPRD (in vitro)

		RIMS2	CACNA1S
Gene Name		regulating synaptic membrane exocytosis 2	calcium channel, voltage-dependent, L type, alpha 1S subunit
Image
Gene Ontology Annotations	Cellular Component	Cell Junction Presynaptic Membrane Presynaptic Active Zone Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Sarcoplasmic Reticulum T-tubule I Band
	Molecular Function	Protein Binding Rab GTPase Binding Ion Channel Binding Metal Ion Binding	Voltage-gated Calcium Channel Activity High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium Ion-dependent Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Skeletal System Development Extraocular Skeletal Muscle Development Calcium Ion Transport Muscle Contraction Striated Muscle Contraction Endoplasmic Reticulum Organization Axon Guidance Myoblast Fusion Neuromuscular Junction Development Regulation Of Ion Transmembrane Transport Skeletal Muscle Adaptation Skeletal Muscle Fiber Development Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways			NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Permanent tooth development ( 21931568)
Protein-Protein Interactions		12 interactors: ABCA1 CACNA1S RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH	4 interactors: PDZD3 RIMS2 RYR1 SRI
Entrez ID		9699	779
HPRD ID		09436	00248
Ensembl ID			ENSG00000081248
Uniprot IDs		Q9UQ26	B1ALM3 Q13698
PDB IDs		1V27 1WFG	2VAY
Enriched GO Terms of Interacting Partners?		Protein Secretion Regulation Of Exocytosis Secretion By Cell Rab Protein Signal Transduction Vesicle Docking Involved In Exocytosis Exocytosis Secretion Regulation Of Vesicle-mediated Transport Vesicle Docking Membrane Docking Synaptic Vesicle Transport Protein Transport Establishment Of Protein Localization Synaptic Vesicle Exocytosis Regulation Of Cellular Localization Regulation Of Secretion Protein Localization Establishment Of Vesicle Localization Vesicle Localization Establishment Of Localization In Cell Ras Protein Signal Transduction Vesicle-mediated Transport Intracellular Protein Transport Neurotransmitter Secretion Intracellular Transport Cellular Localization Small GTPase Mediated Signal Transduction Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Neurotransmitter Transport Positive Regulation Of Transport Organelle Localization Cellular Protein Localization Cell-cell Signaling Transport Positive Regulation Of Regulated Secretory Pathway Synaptic Transmission Intracellular Signal Transduction Peptidyl-cysteine Methylation Regulation Of Regulated Secretory Pathway Positive Regulation Of Exocytosis Regulation Of Synaptic Transmission Response To Stimulus Positive Regulation Of Secretion Endomembrane System Organization Signal Transduction Regulation Of Synaptic Plasticity Signaling Cell Communication Vesicle Organization	Cyclic-nucleotide-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity Second-messenger-mediated Signaling Regulation Of Ion Homeostasis Intracellular Sequestering Of Iron Ion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Membrane Potential Muscle Organ Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transport Regulation Of High Voltage-gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Relaxation Of Muscle Ion Transport Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Cellular Metal Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Regulation Of Ion Transmembrane Transport Transport Cellular Cation Homeostasis Regulation Of Cell Communication By Electrical Coupling Cellular Ion Homeostasis Regulation Of Inhibitory Postsynaptic Membrane Potential Metal Ion Homeostasis Negative Regulation Of Transcription Regulatory Region DNA Binding Muscle Structure Development Heart Development Ossification Involved In Bone Maturation Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Chemical Homeostasis Bone Maturation Ion Homeostasis Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Cytoplasmic Sequestering Of Transcription Factor Regulation Of CGMP Biosynthetic Process CAMP-mediated Signaling Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Negative Regulation Of Lyase Activity Cellular Localization Regulation Of Ion Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Tagcloud ?			aftn autonomously carry channel defects encoding familial former functioning graves gs gsalpha herein hypokalemic japanese kcne3 latter nodule paralysis periodic potassium rarely resolved stimulatory thyrotoxic thyrotropin tpp tshr understood
Tagcloud (Difference) ?			aftn autonomously carry channel defects encoding familial former functioning graves gs gsalpha herein hypokalemic japanese kcne3 latter nodule paralysis periodic potassium rarely resolved stimulatory thyrotoxic thyrotropin tpp tshr understood
Tagcloud (Intersection) ?