RIMS2 and RAB3B

Number of citations of the paper that reports this interaction (PubMedID 12578829)
0

Data Source:
HPRD (in vitro)

		RIMS2	RAB3B
Description		regulating synaptic membrane exocytosis 2	RAB3B, member RAS oncogene family
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Extracellular Exosome Presynaptic Active Zone Cytoplasmic Component	Cytoplasm Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Synaptic Vesicle Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Dopaminergic Synapse
	Molecular Function	Protein Binding Zinc Ion Binding Small GTPase Binding Transmembrane Transporter Binding Metal Ion Binding Structural Constituent Of Presynaptic Active Zone	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Exocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Synaptic Vesicle Docking Synaptic Vesicle Priming Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Cell Differentiation Regulation Of Membrane Potential Maintenance Of Presynaptic Active Zone Structure Calcium Ion-regulated Exocytosis Of Neurotransmitter Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Exocytosis Protein Transport Regulation Of Exocytosis Antigen Processing And Presentation Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Vesicle Size Regulation Of Synaptic Vesicle Cycle
Pathways			RAB geranylgeranylation
Drugs
Diseases
GWAS		Cocaine dependence ( 23958962) Dietary fat liking ( 32516399) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High density lipoprotein cholesterol levels ( 30498476) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple system atrophy (pathologically confirmed) ( 27629089) Parkinson's disease progression (cognitive) ( 33958783)	Mean platelet volume ( 32888494)
Interacting Genes		13 interacting genes: ABCA1 CACNA1S EGFR RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH	15 interacting genes: ACVR1 CALM1 CALM2 CALM3 CHM GDI1 PIGR RIMS2 RPH3A RPH3AL SGSM2 SMAD1 SMAD4 TGFBR1 VRTN
Entrez ID		9699	5865
HPRD ID		09436	01540
Ensembl ID		ENSG00000176406	ENSG00000169213
Uniprot IDs		A0A8Q3SIU4 A0A8Q3SJ53 A0A994J503 A0A994J5M6 A0A994J7W6 F8W6W8 Q9UQ26	P20337
PDB IDs		1V27 1WFG	3DZ8 8A4B 8A4C
Enriched GO Terms of Interacting Partners?		Myosin V Binding Exocytosis Secretion By Cell Secretion Regulation Of Exocytosis Establishment Of Protein Localization Synaptic Vesicle Protein Transport GTP-dependent Protein Binding Endosome Positive Regulation Of Regulated Secretory Pathway Regulation Of Transport Vesicle-mediated Transport GTPase Activity Regulation Of Vesicle-mediated Transport Regulation Of Secretion By Cell Intracellular Protein Localization GTP Binding Regulation Of Secretion Positive Regulation Of Exocytosis Positive Regulation Of Transport Nucleotide Binding Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Regulation Of Regulated Secretory Pathway Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Plasma Membrane Membrane Peptide Secretion GDP Binding Presynapse Golgi Apparatus Regulation Of Synaptic Vesicle Cycle Peptide Transport Antigen Processing And Presentation Small GTPase Binding Regulation Of Biological Quality Secretory Granule Regulated Exocytosis Vesicle Organization Intracellular Vesicle Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Perinuclear Region Of Cytoplasm Amide Transport Signal Release Calcium-ion Regulated Exocytosis Regulation Of Vesicle Fusion Synaptic Vesicle Transport	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Adenylate Cyclase Activator Activity Myelin Sheath Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Small GTPase Binding Vesicle-mediated Transport Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling I-SMAD Binding Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Negative Regulation Of Transporter Activity Calcium Channel Complex Transforming Growth Factor Beta Receptor Signaling Pathway Protein-containing Complex Calcineurin-mediated Signaling Activin Receptor Signaling Pathway Detection Of Chemical Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intracellular Signaling Cassette Regulation Of Regulated Secretory Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Synaptic Vesicle Membrane Response To Calcium Ion Transmembrane Transporter Binding Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Spindle Microtubule Transforming Growth Factor Beta Receptor Activity, Type I Presynaptic Endocytosis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Substantia Nigra Development Calcium Channel Regulator Activity SMAD Binding Sperm Midpiece Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Spontaneous Neurotransmitter Secretion
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