PIM2 and FBXO18

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PIM2	FBXO18
Gene Name		Pim-2 proto-oncogene, serine/threonine kinase	F-box protein, helicase, 18
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding	DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Male Meiosis Regulation Of Mitotic Cell Cycle Cell Proliferation Negative Regulation Of Cell Proliferation Apoptotic Mitochondrial Changes Response To Virus Positive Regulation Of Autophagy Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization	DNA Catabolic Process, Endonucleolytic Positive Regulation Of Protein Phosphorylation DNA Duplex Unwinding Response To Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 20453838)
Protein-Protein Interactions		11 interactors: ATXN1 BAD CUTC FBXO18 GSK3B HNRNPH3 IKBKG NDUFB8 RPL21 SOCS1 ZNF821	8 interactors: CUL1 PIM2 RAD51 RBX1 RPL13A SKP1 UBC ZDHHC17
Entrez ID		11040	84893
HPRD ID		02244	06243
Ensembl ID		ENSG00000102096	ENSG00000134452
Uniprot IDs		Q9P1W9	B3KV95 Q2TAK1 Q8NFZ0
PDB IDs		2IWI
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorylation Nucleobase-containing Compound Metabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Phosphorus Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Fc-epsilon Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Fc Receptor Signaling Pathway Response To Biotic Stimulus Regulation Of Kinase Activity Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Innate Immune Response Positive Regulation Of Phosphorylation Regulation Of Immune Response Cellular Response To Chromate Cellular Response To Mechanical Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Phosphorylation Negative Regulation Of Intracellular Signal Transduction Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Type B Pancreatic Cell Development Suppression By Virus Of Host Apoptotic Process Superior Temporal Gyrus Development Regulation Of Protein Phosphorylation Regulation Of Glucose Metabolic Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Response To Amino Acid Establishment Of Localization In Cell Nuclear Export Cellular Metabolic Process Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Negative Regulation Of Signaling Fat Cell Differentiation	SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Notch Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Protein Monoubiquitination Viral Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Macromolecule Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Circadian Rhythm Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Catabolic Process Protein Modification By Small Protein Conjugation Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Mitotic Cell Cycle Process Cellular Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mitotic Cell Cycle Positive Regulation Of Proteolysis Rhythmic Process Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Modification Process Regulation Of DNA-templated Transcription In Response To Stress Response To Stimulus Regulation Of Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Formation Of Translation Preinitiation Complex
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Tagcloud (Difference) ?		afrikaans arrival asystole bathing baths bradycardia buckets cape cpr dangers deserves drowned drowning happened incidents inotropes memorial pools pupils resuscitative speaking submersion supervision town unresponsive unwitnessed victim witnessed xhosa
Tagcloud (Intersection) ?