PIM2 and CUTC

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PIM2	CUTC
Description		Pim-2 proto-oncogene, serine/threonine kinase	cutC copper transporter
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GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Copper Ion Binding Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Apoptotic Mitochondrial Changes Response To Virus Positive Regulation Of Autophagy Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Protein Stabilization	Copper Ion Transport Protein Tetramerization Copper Ion Homeostasis
Pathways			Ion transport by P-type ATPases
Drugs
Diseases
GWAS			Colorectal cancer ( 26151821) Crohn's disease ( 22412388) Obesity-related traits ( 23251661)
Interacting Genes		16 interacting genes: ATXN1 BAD CUTC DAPK1 FBH1 FBP1 FBXO7 GSK3B HNRNPH3 HSF1 IKBKG NDUFB8 RPL21 SOCS1 TRIM14 ZNF821	19 interacting genes: ASCC2 ATXN1 BCL6 CDC37 CEP76 CFTR KANK2 LNX1 MEOX2 MESD NADSYN1 NIF3L1 NTAQ1 NUDT18 PICK1 PIM2 SDCBP SLC27A6 SPG21
Entrez ID		11040	51076
HPRD ID		02244	13100
Ensembl ID		ENSG00000102096	ENSG00000119929
Uniprot IDs		Q9P1W9	Q9NTM9
PDB IDs		2IWI 4X7Q	3IWP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Autophagy Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Protein Kinase Binding Regulation Of Cellular Response To Stress Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Cell Development Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Cellular Response To Heat Positive Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Stress Positive Regulation Of Apoptotic Signaling Pathway Nucleus Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Hemopoiesis Positive Regulation Of Proteolysis Positive Regulation Of Cell Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Cell Differentiation Cellular Response To Lipid DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Microtubule Anchoring At Centrosome Cellular Response To Nitroglycerin Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Primary Metabolic Process Regulation Of Lymphocyte Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
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