PIM2 and NDUFB8

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PIM2	NDUFB8
Description		Pim-2 proto-oncogene, serine/threonine kinase	NADH:ubiquinone oxidoreductase subunit B8
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GO Annotations	Cellular Component	Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Respiratory Chain Complex I
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Apoptotic Mitochondrial Changes Response To Virus Positive Regulation Of Autophagy Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Protein Stabilization	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways			Mitochondrial protein import Mitochondrial protein import Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Palmitoleic acid (16:1n-7) levels ( 23362303)
Interacting Genes		16 interacting genes: ATXN1 BAD CUTC DAPK1 FBH1 FBP1 FBXO7 GSK3B HNRNPH3 HSF1 IKBKG NDUFB8 RPL21 SOCS1 TRIM14 ZNF821	6 interacting genes: ATP6V0D2 CACNA1A EIF2B3 PFN2 PIM2 ZAP70
Entrez ID		11040	4714
HPRD ID		02244	11886
Ensembl ID		ENSG00000102096	ENSG00000166136
Uniprot IDs		Q9P1W9	O95169
PDB IDs		2IWI 4X7Q	5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Autophagy Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Protein Kinase Binding Regulation Of Cellular Response To Stress Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Cell Development Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Cellular Response To Heat Positive Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Stress Positive Regulation Of Apoptotic Signaling Pathway Nucleus Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Hemopoiesis Positive Regulation Of Proteolysis Positive Regulation Of Cell Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Cell Differentiation Cellular Response To Lipid DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Microtubule Anchoring At Centrosome Cellular Response To Nitroglycerin Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Primary Metabolic Process Regulation Of Lymphocyte Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
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