PIM2 and NDUFB8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PIM2	NDUFB8
Gene Name		Pim-2 proto-oncogene, serine/threonine kinase	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Endoplasmic Reticulum Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding	NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Male Meiosis Regulation Of Mitotic Cell Cycle Cell Proliferation Negative Regulation Of Cell Proliferation Apoptotic Mitochondrial Changes Response To Virus Positive Regulation Of Autophagy Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization	Mitochondrial Electron Transport, NADH To Ubiquinone Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways			Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS			Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		11 interactors: ATXN1 BAD CUTC FBXO18 GSK3B HNRNPH3 IKBKG NDUFB8 RPL21 SOCS1 ZNF821	6 interactors: ATP6V0D2 CACNA1A EIF2B3 PFN2 PIM2 ZAP70
Entrez ID		11040	4714
HPRD ID		02244	11886
Ensembl ID		ENSG00000102096	ENSG00000166136
Uniprot IDs		Q9P1W9	O95169
PDB IDs		2IWI
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorylation Nucleobase-containing Compound Metabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Phosphorus Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Fc-epsilon Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Fc Receptor Signaling Pathway Response To Biotic Stimulus Regulation Of Kinase Activity Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Innate Immune Response Positive Regulation Of Phosphorylation Regulation Of Immune Response Cellular Response To Chromate Cellular Response To Mechanical Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Phosphorylation Negative Regulation Of Intracellular Signal Transduction Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Type B Pancreatic Cell Development Suppression By Virus Of Host Apoptotic Process Superior Temporal Gyrus Development Regulation Of Protein Phosphorylation Regulation Of Glucose Metabolic Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Response To Amino Acid Establishment Of Localization In Cell Nuclear Export Cellular Metabolic Process Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Negative Regulation Of Signaling Fat Cell Differentiation	Regulation Of Neurotransmitter Secretion Cerebellar Molecular Layer Development Vestibular Nucleus Development Beta Selection Regulation Of Exocytosis Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Protein Autophosphorylation Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Negative Regulation Of Ruffle Assembly Negative Regulation Of Translational Initiation In Response To Stress Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Negative Regulation Of Translation In Response To Stress Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Regulation Of Synaptic Transmission Positive Thymic T Cell Selection Negative Regulation Of Hormone Biosynthetic Process Regulation Of Translational Initiation In Response To Stress Pons Development Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Thymic T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation Cerebellar Purkinje Cell Differentiation Negative T Cell Selection Regulation Of Translation In Response To Stress Cellular Metal Ion Homeostasis Cerebellar Purkinje Cell Layer Morphogenesis Regulation Of Ruffle Assembly T Cell Migration Negative Regulation Of Translational Initiation Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Reflex Metal Ion Homeostasis Behavioral Response To Pain Thymic T Cell Selection Regulation Of Cell Projection Organization Response To Peptide Neuromuscular Synaptic Transmission
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Tagcloud (Difference) ?		afrikaans arrival asystole bathing baths bradycardia buckets cape cpr dangers deserves drowned drowning happened incidents inotropes memorial pools pupils resuscitative speaking submersion supervision town unresponsive unwitnessed victim witnessed xhosa
Tagcloud (Intersection) ?