CHAT and NEDD9

Number of citations of the paper that reports this interaction (PubMedID 10692442)
0

Data Source:
HPRD (in vivo)

		CHAT	NEDD9
Description		choline O-acetyltransferase	neural precursor cell expressed, developmentally down-regulated 9
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Neuron Projection Synapse	Spindle Pole Immunological Synapse Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Membrane Basolateral Plasma Membrane Lamellipodium Ciliary Basal Body Cell Projection Anchoring Junction Mitotic Spindle
	Molecular Function	Choline O-acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity	Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Phosphatidylcholine Biosynthetic Process Neurotransmitter Transport Neuromuscular Synaptic Transmission Acetylcholine Biosynthetic Process	Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Learning Or Memory Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Osteoclast Differentiation Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Cilium Disassembly Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dendritic Spine Maintenance Positive Regulation Of Protein Localization Positive Regulation Of Immunological Synapse Formation
Pathways		Synthesis of PC Acetylcholine Neurotransmitter Release Cycle
Drugs		Nicotine
Diseases		Congenital myasthenic syndrome
GWAS		Glaucoma (primary angle closure) ( 27064256) Interleukin-1-receptor antagonist levels ( 22205395) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes nephropathy ( 30566433)	Childhood dental caries in permanent teeth ( 29931343) Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HIV-1 susceptibility ( 22174851) Macular thickness ( 30535121) Prostate cancer ( 25217961) Small cell lung carcinoma ( 28604730)
Interacting Genes		9 interacting genes: CAMK2A CAMK2G NEDD9 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ	70 interacting genes: ABL1 ACTMAP ANKS1A APP AURKA BANP BCAR1 BCAR3 CDC42EP2 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 DOCK9 DPPA4 EEIG1 ELSPBP1 EXOSC8 FAM168B FOSB FYN FZR1 HOXA1 ID2 INCA1 ITCH KLHL20 KRT32 LCK LHX8 LYN MED19 MICAL1 NAB2 NBPF19 NCK1 NFKBIA NOTCH2NLA NOTCH3 PEX14 PIK3CA PIK3R3 PRAM1 PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 SNAPIN TBX19 TCF3 TFCP2 TRAF2 TRIM23 TRIM27 TRIP6 WWOX ZNF76 ZYX
Entrez ID		1103	4739
HPRD ID		07510	11888
Ensembl ID		ENSG00000070748	ENSG00000111859
Uniprot IDs		P28329 Q6LEN5 Q6LEN6	A0A087WUD2 Q14511
PDB IDs		2FY2 2FY3 2FY4 2FY5 7AMD	2L81 5X3S
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Protein Phosphorylation Long-term Synaptic Potentiation Phosphorylation Regulation Of Synaptic Plasticity ATP Binding Regulation Of Protein Localization Histone H3T6 Kinase Activity Nucleotide Binding Regulation Of Biological Quality Transferase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transport Positive Regulation Of Immune System Process Regulation Of Secretion By Cell Positive Regulation Of Protein Transport Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Regulation Of Secretion Response To Hormone Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Neurotransmitter Secretion Positive Regulation Of Insulin Secretion Mitotic Nuclear Membrane Disassembly Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization Insulin Receptor Substrate Binding Positive Regulation Of Peptide Hormone Secretion Nuclear Membrane Disassembly Positive Regulation Of Peptide Secretion Membrane Disassembly Phosphate-containing Compound Metabolic Process Regulation Of Protein Localization To Plasma Membrane Response To Morphine	Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cytosol Cell Surface Receptor Signaling Pathway Response To Growth Factor Antigen Receptor-mediated Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Leukocyte Activation Cell Activation Positive Regulation Of Metabolic Process T Cell Receptor Signaling Pathway Cell Migration Response To Transforming Growth Factor Beta Signal Complex Assembly Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Positive Regulation Of RNA Biosynthetic Process ERBB Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Immune Response Lymphocyte Activation Intracellular Signaling Cassette Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intracellular Signal Transduction Endothelin Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Integrin-mediated Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Cell Motility Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Nucleus Signal Transduction Regulation Of Metabolic Process
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